Longevity
Large-scale Plasma Proteomics Links Physical Activity to Proteins Associated with Dementia Risk
Across three cohorts totaling over 11,000 participants, plasma proteomics using the SomaScan 7k platform (measuring…
Studies
PEGylated Liposomal Resveratrol Reduces Select Brain ROS But Fails to Rescue ASD Behaviors in VPA Rat Model
A rat model of autism spectrum disorder (ASD), induced via prenatal valproic acid (VPA) exposure, received PEGylated…
Longevity
Narrative Review Maps IF Protocols to AMPK-mTOR-SIRT1 Pathways for Cardiometabolic Health
Four IF protocols — TRE (16/8), alternate-day fasting, 5:2, and OMAD — converge on a shared molecular architecture…
Longevity
Single-Cell Map Reveals Progressive Vascular Collapse Mechanism in Progeria
Understanding why children with Hutchinson-Gilford Progeria Syndrome invariably die of cardiovascular disease — and…
Studies
Study Maps Protective Niches Harboring Dormant Breast Cancer Cells Near Immune and Stromal Cells
Understanding why breast cancer returns years after apparent remission is one of oncology's most vexing problems. This…
Studies
MYC Phosphorylation at Serine 62 Drives DNA Repair in Cancer Cells
One of oncology's most persistent puzzles is how MYC — the transcription factor gone rogue in virtually every human…
Nutrition
Pulse- vs Meat-Protein Diets Show Similar Cardiometabolic Benefits in Older Adults, With Possible Ferritin Edge for Pulses
For older adults navigating the intersection of cardiovascular risk and metabolic aging, protein source may matter as…
Longevity
TRF2 Protein Controls Muscle Stem Cell Fate Beyond Telomere Protection
The capacity to rebuild damaged muscle tissue erodes with age and disease, making the molecular switches governing…
Studies
Focused Ultrasound Unlocks Blood-Brain Barrier for Precision Neurological Drug Delivery
For decades, the blood-brain barrier has been the single greatest pharmacological obstacle in neurology — a fortress…
Studies
Congo Basin Conflict Accelerates Zoonotic Spillover Across 15 Known Pathogens
Few regions on Earth concentrate as many converging health risks as the Congo Basin — and most of the world has been…
PREPRINTSupplements
Glucosamine's Alzheimer's Link May Reflect Supplement-User Bias, Not Causation
Reanalysis of a National Alzheimer's Coordinating Center cohort reveals that the association between documented…
PREPRINTLongevity
Blood p-tau 217 Predicts Alzheimer's 20 Years Early With 80% Accuracy
Brain-derived phosphorylated tau 217 (p-tau 217), measured in blood samples from 213 Alzheimer's cases and 213 matched…
PREPRINTFitness
Blue-Collar Workers Move More at Work, Less at Leisure: 2,809-Person Accelerometry Study
Accelerometry data from 2,809 adults in the Northern Finland Birth Cohort 1966 (46-year follow-up) reveals stark…
PREPRINTStudies
Protocol Registered for Study of Optimized Methadone/Buprenorphine Titration Schedules in Fentanyl Era
A protocol paper registered on medRxiv describes a planned population-based retrospective cohort study using linked…
PREPRINTNutrition
Stool DNA Sequencing Reveals Personal Food Profiles With 72% Participation Rate
The Everyone EATS pilot study demonstrated that stool-derived DNA sequencing can reconstruct individual diets at…
Longevity
IRF1 Activates PI3K/AKT to Drive Bone Stem Cell Osteogenesis, Reversing Osteoporosis
Overexpression of interferon regulatory factor 1 (IRF1) in murine bone marrow mesenchymal stem cells (mBMSCs) enhanced…
Supplements
New GLP-1 Drug TE-8105 Achieves 120-Hour Half-Life in Phase 1 Trial, Supporting Potential Biweekly Dosing
A phase 1 first-in-human trial of TE-8105 — a novel long-acting GLP-1 receptor agonist — tested four single ascending…
Longevity
Study Links Adverse Weather to Reversible Telomere Shortening in Dairy Goats
In 20 pluriparous Alpine dairy goats monitored across three 15-day intervals, acute environmental stress produced…
Longevity
Larger Social Networks Linked to Better Cognition in Older Men But Smaller Hippocampal Volume in Women
In 104 older adults (mean age 73.8; 60 female), greater social network size—measured via the Social Network Index—was…
Supplements
0.1 μM Resveratrol Fully Reverses Radiation-Induced Endothelial DNA Damage In Vitro
At a strikingly low concentration of 0.1 μM — far below typical supplementation doses — resveratrol completely rescued…
Browse Topics
Longevity & Anti-Aging Research Nutrition & Diet Science Exercise & Fitness Science Wellbeing & Integrative Health Medical Studies & Clinical Trials Supplements & Nutraceuticals✉️ Stay Updated
Get daily health research summaries delivered to your inbox.
Health & Longevity Topics
Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.