Studies
Chloride Ion Co-Transport With Serotonin Reshapes SERT Mechanism Understanding
For the tens of millions of people taking SSRIs or other serotonin-targeting antidepressants, the molecular machinery…
Studies
Farm Soil Management Directly Controls Antibiotic Resistance Gene Spread
Antibiotic resistance is one of medicine's most pressing threats, and most attention has focused on hospitals and…
Studies
SIRT2 Enzyme Modulation Blocks EBV-Driven B Cell Transformation Linked to 200,000 Cancer Deaths
Epstein-Barr virus quietly persists in nearly all adults, yet for roughly 200,000 people annually it triggers cancers…
Studies
RNA Modification Loss in Mitochondria Triggers Epithelial Autoimmune Inflammation
Understanding why the body's own tissues become targets in autoimmune disease has long eluded researchers, and most…
Studies
Cryo-EM Reveals How GSDME Pore Forms and How Palmitoylation Brakes It
Understanding how cells decide between a quiet death and an inflammatory one has enormous implications for cancer…
Studies
YBX1 Protein Shields Cells From Their Own Inflammatory RNA Signals
Most inflammatory research focuses on external threats — viruses, bacteria, environmental toxins — yet some of the…
Studies
Microgravity Rewires Inner Ear Saccule Genes, Explaining Astronaut Balance Loss
Balance disorders after spaceflight are among the most consistent and debilitating effects astronauts report upon…
Wellbeing
Firearm Violence Hot Spots Linked to Persistent Youth Suicide Risk Post-Pandemic
While the broader conversation about pandemic-era mental health has focused on whether youth are recovering, a…
Studies
Surgical and Endoscopic GERD Interventions: Comparative Efficacy Across Five Techniques
For the estimated 20% of Western adults living with chronic gastroesophageal reflux disease, medication dependency is…
Studies
EHR Menopause Data Gaps Undermine Clinical Care and Research Quality
The quality of menopause research and clinical management depends entirely on whether health systems are reliably…
Studies
Thrombectomy Extends Stroke Benefits to Smaller, Harder-to-Reach Arterial Blockages
For decades, mechanical thrombectomy transformed outcomes for large-vessel stroke — but millions of patients with…
Wellbeing
Irritability and Negative Thinking Link ADHD to Depression Across Three Life Stages
Understanding why ADHD so frequently precedes depression has long been one of the more pressing unsolved questions in…
Studies
Thrombectomy for Small-Vessel Stroke: RCT Challenges Current Treatment Boundaries
For decades, mechanical thrombectomy — the catheter-based removal of blood clots — has been a cornerstone of…
Studies
Global TB Burden Mapped Across 204 Nations: MDR-TB Progress Falling Short
Tuberculosis remains one of the most consequential but underappreciated threats to global longevity, and this sweeping…
Studies
Text-Delivered Safe Sleep Videos Cut Unsafe Infant Practices in WIC Families
Sudden unexpected infant death remains one of the most preventable tragedies in early childhood, yet safe sleep…
Studies
Alpha-Synuclein Inclusions Show Regional Diversity but Shared Ultrastructure Across Lewy Diseases
Understanding why two diseases shaped by the same misfolded protein — α-synuclein — produce such different clinical…
Studies
Social Vulnerability Tied to Lower Buprenorphine Doses in Fentanyl Era
As fentanyl has displaced heroin across the U.S. drug supply, the clinical calculus for treating opioid use disorder…
Longevity
Aging Diseases Show Compounding Returns: Tackling One Amplifies Gains Against Others
A conceptual shift in how we classify disease burden may fundamentally alter where global health investment flows…
Studies
RNA Splicing Defect in Fat-Tissue Macrophages Sabotages Weight Loss After Obesity
Why some people struggle to shed residual fat even after meaningful weight loss may owe less to willpower or…
PREPRINTLongevity
Liver Fat Splits T2D and CAD Risk via ApoB Lipoprotein Export Mechanism
Analyzing 378,772 UK Biobank participants alongside multi-ancestry GWAS data, researchers identified 149 genetic loci…
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Health & Longevity Topics
Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.