Studies
Antibody-Light Conjugate Eliminates Key Periodontal Pathogen Without Disrupting Oral Microbiome
The ability to surgically target a single bacterial species within a complex microbial community — without collateral…
Studies
Daraxonrasib Resistance Mechanisms Illuminate Combination Therapy Paths in Pancreatic Cancer
Pancreatic cancer remains one of oncology's most intractable challenges, with five-year survival rates stubbornly…
Studies
Dual-AAV Otoferlin Gene Therapy Restores Hearing in Mice, Enters Human Trials
For families affected by DFNB9-related congenital deafness — a condition that silences children from birth — gene…
Longevity
TNFR1-Driven Inflammation Disrupts Fatty Acid Metabolism in Aging Gut Stem Cells
Gut health in older adults may be more tightly tied to systemic inflammation than previously understood — and a newly…
Studies
Global TB Burden Mapped Across 204 Nations: MDR-TB Progress Stalls Before 2035 Target
Tuberculosis remains one of humanity's most consequential infectious disease failures — a curable disease that still…
Nutrition
First-1000-Days Sugar Restriction Linked to 27–46% Lower Dementia Risk Decades Later
What adults eat in the first years of life may shape their brain's vulnerability to dementia and psychiatric illness…
PREPRINTStudies
cLFLG Subtype Associated with MR Worsening After TAVR in 614-Patient Study
Among 614 low-flow aortic stenosis (LFAS) patients undergoing transcatheter aortic valve replacement (TAVR), mitral…
PREPRINTStudies
Llama 3.3 70B Achieves 100% Sensitivity Identifying PCI Procedures in Clinical Notes; Near-Perfect for Complex Cases
A large language model — Llama 3.3 70B — achieved 100% sensitivity and 93.8% specificity in identifying percutaneous…
PREPRINTLongevity
Neighborhood Gun Violence Associated with 0.5% Lower Endothelial Function in Black Teens, with Diet and Adiposity as Mediators
In a prospective cohort of 400 Black adolescents from lower-income Chicago households, exposure to neighborhood gun…
PREPRINTStudies
PCAT Fat Imaging Biomarker Decoupled from Local Coronary IL-6 and IL-1β in Stable CAD
In 31 adults with stable coronary artery disease, pericoronary adipose tissue (PCAT) attenuation measured on CT…
PREPRINTStudies
ICU High-Intensity Statins Associated With Modest AKI Risk Increase in ACS Patients, Especially During Instability
Among 5,178 critically ill patients with acute coronary syndrome across three major ICU databases (MIMIC-IV, eICU…
Longevity
Smoking and Aging Share 85 Gut Microbiome Signatures Linked to ASCVD Risk
Analyzing 6,676 participants from the Guangdong Gut Microbiome Project, this cross-sectional study identified 222 OTUs…
Longevity
Fibrillarin-SIRT1 Axis Blocks Tumor Senescence via NAD+ Metabolism in ESCC
In esophageal squamous cell carcinoma (ESCC) patient cohorts, high intratumoral expression of fibrillarin (FBL), a…
Longevity
CSDH Mapped to Aging Hallmarks: Geroscience Framework Suggests Senolytic Research Targets
Chronic subdural hematoma (CSDH) — a blood collection beneath the skull's inner lining — is projected to become the…
Studies
Antigenically Drifted H3N2 Subclade K Associated with Reduced Vaccine Effectiveness in 2025-2026 Flu Season
Vaccine mismatch is one of the most consequential—and underappreciated—variables in seasonal influenza protection…
Studies
New Bundibugyo Ebolavirus Variant Confirmed in 2026 DRC-Uganda Outbreak via Genomic Analysis
When a hemorrhagic fever outbreak crosses an international border, the question of whether it represents a known…
Longevity
ACE2 Overexpression Protects Against Cardiac Aging Injury in K18-hACE2 Transgenic Mice
Most adults know ACE2 as the receptor SARS-CoV-2 exploits to enter cells, but this enzyme has a far older and more…
Studies
Oncolytic Viruses Reshape Tumor Immunity via Two-Pronged Kill Mechanism
As global cancer incidence approaches 30 million new annual cases by mid-century, conventional oncology's persistent…
Longevity
Aging Stem Cells Hijack Immune Memory to Drive Chronic Inflammation via SIRT3 Loss
Chronic low-grade inflammation — inflammaging — has long been recognized as a root driver of age-related disease, but…
Studies
Five HIV Reservoir Phenotypes Linked to Distinct Inflammatory Immune Signatures
For the roughly 39 million people living with HIV globally, viral suppression via antiretroviral therapy is no longer…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.