Wellbeing
One Month Alcohol Abstinence Cuts Liver Enzymes by 60% in ALD Patients
In a prospective cohort of 72 adults with confirmed alcoholic liver disease (ALD) at a Kathmandu rehabilitation…
Studies
T2D Remission Cuts Vascular Risk 27–32% Across Lifestyle and Surgery Pathways
Across eight reports from seven independent longitudinal cohorts, achieving biochemical remission of type 2 diabetes…
Longevity
Bariatric Surgery Cuts Dementia Risk 52%, Parkinson's 30% in Obese Adults
Among 32,552 propensity-score-matched pairs of adults with BMI ≥35 kg/m², bariatric surgery was associated with a 52%…
PREPRINTSupplements
Boosting Glycolysis in Osteoblasts Reverses Age-Related Bone Loss in Mice
In aged mice, bone formation declines in tandem with a measurable impairment of glycolysis within bone tissue itself…
PREPRINTSupplements
Rapamycin, Canagliflozin & Caloric Restriction Alter Canine Immune Markers at 90 Days
In a controlled cross-sectional cohort of 80 intact Beagles aged 1–11 years, immune aging proved heterogeneous and…
PREPRINTSupplements
Dual SGLT1/2 Inhibitor Sotagliflozin Cuts Atherosclerosis Via Hepatic Fat Reprogramming
In a mouse model of cardiovascular-kidney-metabolic (CKM) syndrome, sotagliflozin — the only SGLT inhibitor shown to…
PREPRINTFitness
Voluntary Running Cuts Glucose Intolerance 35% in Obese Mice — Gut Microbiome Mediates Effect
In three genetically distinct BXD mouse strains fed a 60% fat diet for 32 weeks, voluntary wheel running (~5 km/day…
Fitness
Each 1-MET Fitness Gain Cuts 10-Year Death Risk by 16% in 562,000 Adults
In the largest exercise-testing cohort to date — 562,234 adults followed for a mean 10.2 years — each additional MET…
Nutrition
Stearic Acid Lowers Cholesterol via FXR Pathway, Not Just Microbiome
In a crossover RCT of 17 mildly hypercholesterolemic postmenopausal women, five-week diets enriched in stearic acid…
Nutrition
Ketogenic Diet Yields 2–3× Greater Liver Insulin Benefit Than Mediterranean at Equal Weight Loss
In adults with metabolically unhealthy obesity (prediabetes plus hepatic steatosis), ~10% weight loss across three…
PREPRINTWellbeing
Late Bedtime Predicts Visceral Fat in Postmenopausal Women with Obesity
In 122 postmenopausal women (mean age 58.1 years, mean BMI 33.2 kg/m²), later sleep onset was significantly associated…
PREPRINTWellbeing
Lifestyle intervention boosts cognition regardless of Alzheimer's blood biomarker levels
In a secondary analysis of the landmark FINGER randomized controlled trial (N=1,260 at-risk older adults), six core…
PREPRINTWellbeing
MHT Raises Breast Cancer Risk But Cuts Mortality by 28% in 78,000-Woman Trial
In a secondary analysis of 78,209 women from the PLCO Cancer Screening Trial, ever-use of menopausal hormone therapy…
PREPRINTWellbeing
Low Social Connection Ages the Brain 5.8 Years; Heavy Smoking Costs 5 Years
In a cross-sectional analysis of 13,866 adults from the All of Us Research Program, four modifiable lifestyle factors…
PREPRINTSupplements
Only 30–36% Stay on GLP-1 Drugs at 12 Months; Real-World Weight Loss Far Below Trials
Among 743,153 US adults with obesity (no diabetes) who started injectable semaglutide or tirzepatide in 2024, only…
Supplements
Two Fisetin Derivatives Outperform Parent Compound as Senolytics in Aging Mice
Two synthetic derivatives of the natural flavonoid fisetin — SR29384 and SR31133 — demonstrated superior senolytic…
Supplements
Rapamycin, Canagliflozin & Caloric Restriction Shift Immune Markers in Dogs
In a controlled cross-sectional cohort of 80 intact Beagles aged 1–11 years, immune aging proved heterogeneous and…
Wellbeing
Sodium-Tracking App Cuts Blood Pressure in 88 Hypertensive Adults Over 2 Months
An 88-patient parallel RCT tested NamakBan, an Android app enabling self-reported salt intake logging, blood pressure…
Studies
Baxdrostat Cuts Systolic BP by 6.9 mmHg in Resistant Hypertension Meta-Analysis
Pooling five randomized, double-blind, placebo-controlled trials (N = 1,730) — BrigHTN, HALO, BaxHTN, FigHTN, and…
Studies
Coronary Calcium Scoring Sharpens New PREVENT Cardiovascular Risk Equations
Knowing your cardiovascular risk is only as good as the tools used to measure it. The AHA's 2023 PREVENT equations…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.