PREPRINTStudies
Calcium Channel Blockers Reduce Preeclampsia Risk Without Fetal Growth Effects
Mendelian randomization analysis of 16,349 preeclampsia cases reveals calcium channel blockers (CCBs) reduce…
PREPRINTLongevity
First Trial Tests Metformin, Fisetin, Spermidine Against Cellular Aging in 70+ Adults
The REPROGRAM trial will test whether three-week interventions with metformin (1500mg), fisetin (100mg), or spermidine…
Studies
Breast Cancer Incident Cases Forecast to Rise 55% to 3.56 Million by 2050
The trajectory of breast cancer reveals an alarming reality for women's health globally, with projections indicating…
Longevity
Cellular Senescence Drives Alzheimer's Through SASP-Mediated Neuroinflammation
Cellular senescence emerges as a pivotal mechanism accelerating Alzheimer's disease progression through the…
Studies
USP15 Enzyme Drives KRAS-Mutant Lung Cancer Through Metabolic Reprogramming
Understanding how cancer cells rewire their metabolism to fuel aggressive growth has become crucial for developing…
Longevity
Silent Inflammation Now Affects Young Adults, Accelerating Disease Risk
The biological timeline of disease risk has fundamentally shifted, with inflammatory processes traditionally confined…
Wellbeing
Machine Learning Identifies Eight Risk Factors for Cognitive Decline in Telehealth Network
Cognitive assessment through telehealth platforms may soon become more precise and accessible for older adults…
Wellbeing
1°C Warming in Contiguous US Could Generate 329 Million Additional Depression Symptom-Days Annually
Climate anxiety may be just the beginning of a broader mental health crisis as temperatures rise across America. This…
Studies
Encapsulated Mitochondria Therapy Rescues Brain Function in Parkinson's Models
The promise of replacing damaged cellular powerhouses to treat neurodegenerative disease has moved closer to reality…
Studies
Rural Americans Face ~20% Higher Lung Cancer Death Rates Amid Reduced Screening Access
Geographic location increasingly determines lung cancer survival in America, with rural residents experiencing…
Studies
Long COVID Mechanisms Point to Mitochondrial Damage Beyond Viral Persistence
The emergence of long COVID as a chronic health burden affecting millions worldwide reveals how a respiratory virus…
Studies
HIV Treatment Reverses CD4 Cell Exhaustion But Leaves CD8 Dysfunction
Long-term HIV treatment creates a peculiar immune paradox that could reshape how clinicians monitor treatment success…
Studies
Brain Blood Vessel Changes Precede Alzheimer's Pathology in Mice and Parallel Trajectories in Aging Humans
Understanding when brain blood vessels begin changing in Alzheimer's disease could transform early detection…
Studies
Hypoxic Brain Tumors Use Exosomal IGFBP2 to Evade Immune Detection
Brain cancer's most aggressive form may have revealed a critical vulnerability in how it hides from immune…
Studies
Seven Key Factors Predict Disease Burden in Mexican Adults
Understanding what drives multiple chronic diseases could transform how we approach preventive healthcare, especially…
Studies
Brain Cell Map Reveals SLC45A1 as Lysosomal Sugar Transporter
Understanding how cellular recycling centers function differently across brain cell types could revolutionize…
Studies
Machine Learning Reveals Five Diabetes Subtypes With Distinct Mortality Patterns
The standard approach to diabetes classification may be fundamentally inadequate for predicting patient outcomes and…
Studies
96-Week LATA Trial Enrolls African Adolescents to Test Injectable HIV Treatment
Adherence challenges in HIV treatment among adolescents could face a transformative solution through extended-release…
Nutrition
High Intake of Fruits, Vegetables, Legumes, and Potatoes Linked to 56% Lower Crohn's Risk in European Cohort
The path to preventing inflammatory bowel disease may run through the produce aisle, with new evidence suggesting that…
Wellbeing
New Conceptual Framework Proposes P-APGAR to Assess Male-Specific Perinatal Psychosocial Adjustment
Traditional perinatal mental health screening systematically overlooks fathers, creating a dangerous blind spot that…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.