Studies
Genetic Architecture of Coronary Disease Reveals New Therapeutic Targets
Genome-wide association studies have identified over 300 genetic loci linked to coronary artery disease risk, with poly…
Studies
First Oral PCSK9 Inhibitor Enlicitide Reduces LDL Cholesterol 60%
Enlicitide demonstrated a 60% reduction in LDL cholesterol levels compared to placebo in a phase 3 randomized controlle…
Wellbeing
Aging Adults Show 3x Higher Exposure to Health Misinformation Online
Digital health literacy emerges as a critical vulnerability among aging populations, potentially undermining evidence-b…
Wellbeing
Digital Health Literacy Declines With Age, Study Finds
The ability to navigate health information online becomes increasingly critical as digital platforms replace traditiona…
Studies
WHO Analysis Identifies 30 Modifiable Risk Factors Behind 40% Cancer Cases
A comprehensive WHO analysis examining 30 modifiable risk factors reveals that 40% of global cancer cases stem from pre…
Studies
WHO Analysis Identifies 30 Modifiable Risk Factors Preventing 40% Cancers
A comprehensive WHO analysis examining 30 modifiable risk factors reveals that 40% of global cancer cases stem from pre…
Longevity
Multiple Cellular Pathways Drive Stem Cell Decline During Aging Process
Stem cells lose their regenerative potency through five interconnected molecular pathways that accelerate with age. Cel…
Studies
Protein Discovery Reveals How Sleeping Sickness Parasites Evade Immunity
African trypanosomes utilize a sophisticated molecular switch involving variant surface glycoproteins (VSGs) to continu…
Studies
DNA Templates Enable Controlled Silica Nanostructure Assembly Through Electrostatic Guidance
Scientists achieved precise control over silica nanostructure formation by using DNA scaffolds to direct positively cha…
Wellbeing
Kv6.4 Ion Channel Subunit Governs Brain's Inhibitory Network Firing
Kv6.4, a voltage-gated potassium channel subunit, selectively regulates the firing patterns of parvalbumin-positive int…
Studies
Machine Learning Model Identifies Cancer-Driving Single Amino Acid Mutations
A computational framework successfully distinguishes between benign and pathogenic single amino acid substitutions in p…
Research
In This Issue
This issue of the Proceedings of the National Academy of Sciences (PNAS) presents a collection of research articles cov…
Studies
Mitoxyperilysis: New Mitochondrial Death Pathway Links Metabolism and Inflammation
Wang and colleagues identified mitoxyperilysis, a previously unrecognized cell death mechanism triggered when immune st…
Fitness
Vigorous Exercise Beyond 1,300 MET-Minutes Weekly Impairs Cognition Via Lactate
Analysis of UK Biobank participants reveals a precise threshold where vigorous exercise shifts from cognitive protectio…
Studies
Metastatic Cancer Cells Steal Immune Cell Mitochondria for Energy
Metastatic cancer cells actively acquire mitochondria from surrounding immune cells through a previously uncharacterize…
Longevity
Kidney Cytokine Clearance Mechanism Protects Against Inflammatory Damage
Troha et al. discovered that kidneys actively filter pro-inflammatory cytokines from circulation and excrete them in ur…
Nutrition
Bile Acid Pool Size Controls Intestinal Fat Absorption Efficiency
Mouse experiments reveal that bile acid pool size and composition directly regulate intestinal fat absorption through a…
Studies
Chemotherapy-Induced Senescence Drives Cancer Drug Resistance Through TGFβ Pathway
Platinum chemotherapy triggers cellular senescence in ovarian and lung cancer cells, paradoxically promoting malignancy…
Longevity
Molecular Clocks Identify Neuron Types That Defy Age-Related Decline
Researchers developed molecular aging clocks to measure the biological versus chronological age of individual neuron ty…
Longevity
Selective Senescent Cell Elimination Could Enhance Cancer Treatment Outcomes
Researchers have developed methods to selectively eliminate specific populations of senescent cells while preserving th…
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Health & Longevity Topics
Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.