PREPRINTStudies
133,718 ACS Patients: Ticagrelor vs. Prasugrel Show No Credible MACE Difference
A multinational retrospective cohort study across seven claims and EHR databases—ultimately drawing on 133,718 ACS…
PREPRINTLongevity
DNA Methylation Scores Predict Incident ASCVD With ~2× Hazard Ratio in 44,674 Veterans
In the largest epigenome-wide study of cardiovascular risk to date, three DNA methylation risk scores (MRS) derived…
PREPRINTLongevity
4.4M-Person GWAS Finds 166 Novel Heart Failure Loci, Flags Metabolic Drug Targets
A massive multi-ancestry genome-wide association study spanning 345,687 heart failure cases across 4.47 million…
Supplements
Oxyberberine Nanoparticles Reshape Gut Microbiota to Reduce Alzheimer's Cognitive Decline in Mice
The gut-brain axis is rapidly emerging as one of the most consequential frontiers in Alzheimer's disease research, and…
Studies
IL-17-Driven Tumor Cell-Intrinsic Inflammatory Programming Creates an Immunotherapy-Permissive Microenvironment in Ovarian Clear Cell Carcinoma
Ovarian clear cell carcinoma has long frustrated oncologists: it resists most systemic therapies, and immune…
Studies
Real-Time CGM Cuts HbA1c More Than Finger-Stick Testing in Insulin-Treated Type 2 Diabetes
For the tens of millions of people with type 2 diabetes managed on basal insulin, the question of whether continuous…
Studies
CPU-Only 3D Neural Network Segments Brain Tumors in Real-Time Without Specialist Hardware
The gap between cutting-edge medical AI and the clinics that need it most has long been a quiet crisis in…
Studies
Three Systemic Factors Triple Nurses' Medication Error Risk, Meta-Analysis Finds
Medication errors are among the most preventable sources of patient harm in healthcare settings, yet their root causes…
Studies
Amazonian Foragers Show Record-Low COVID Fatality Rate Despite 71% Infection
What if the Western immune system — shaped by decades of antimicrobial environments, processed diets, and low pathogen…
Studies
LITT Adds 3 Months Median Survival in Unresectable Glioblastoma Trial
For the roughly 30% of glioblastoma patients whose tumors are deemed surgically unreachable, treatment options are…
Studies
JN.1 Booster Associated with Readjustment of Existing Memory B Cells Via Somatic Hypermutation
For the hundreds of millions of people who have received multiple COVID-19 vaccines and survived at least one…
Studies
Infant Air Pollution Exposure Linked to Higher Childhood Obesity Risk via Impaired Inhibitory Control in Mexico City Cohort Study
The assumption that childhood obesity stems primarily from diet and sedentary behavior is being quietly dismantled by…
Fitness
Voluntary Exercise Reverses Obesity-Driven Immune Suppression in Lung Tumor Microenvironment
For the roughly 40% of adults with obesity who face elevated lung cancer risk, a growing body of evidence suggests the…
Wellbeing
Hippocampal Damage From Early Trauma May Drive Psychosis Reward Deficits
For the millions of adults living with psychosis-spectrum conditions, negative symptoms — the flattening of…
Studies
Disposable E-Cigarette Youth Users Show Higher Nicotine Dependence, Fruit Flavor Preference
The surge in disposable vaping devices among adolescents has outpaced researchers' understanding of who is using them…
Studies
Major Album Releases Linked to 40% Spike in Chilean Traffic Deaths
Smartphone distraction behind the wheel is notoriously hard to quantify because self-reporting is unreliable and…
Wellbeing
Social Media Peer Support Linked to Lower Pain Interference and Catastrophizing
For the roughly one in five adults living with chronic pain, formal clinical care is rarely the only resource in play…
Wellbeing
Two-Year iCBT Trial Shows Durable Anxiety Relief in Anxious Schoolchildren
Scalable digital mental health tools for children have long promised to close the gap between need and access — but…
Wellbeing
Gaming Addiction Moderates Pathways from Violent Gaming to Emotional Blunting in Adolescents
Emotional blunting in teenagers — the progressive dulling of empathic and affective responses — represents a quiet but…
Studies
Bayesian Reanalysis Finds 89% Probability Cold Platelets Cut Trauma Mortality
When the standard statistical framework says "not significant," a different analytical lens can reveal a more nuanced…
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Health & Longevity Topics
Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.