Studies
Pulmonary Nerve Ablation Shows Promise for Heart Failure Hypertension in Trial
For the millions of adults living with heart failure complicated by pulmonary hypertension, therapeutic options have…
Studies
13 Blood Markers Predict HFrEF Subtype Before Echocardiography With 0.789 AUC
Distinguishing heart failure subtypes quickly has real consequences: patients with reduced ejection fraction respond…
PREPRINTLongevity
HDL-Remodeling Metabolite Pattern Linked to 17% Higher Dementia Risk in T2D Subtypes (medRxiv Preprint)
Among 7,671 UK Biobank participants with type 2 diabetes (mean age ~60), NMR-based metabolomic profiling across…
PREPRINTLongevity
IHD Deaths Rising in West Africa Since 2007 as Global Rates Fall 38%
While global stroke and ischemic heart disease (IHD) mortality dropped 51.7% and 38.2% respectively between 1990 and…
PREPRINTStudies
Digital Ad Spend Yields Only 36 Black, 27 Latino Recruits per $100K in AF Trial
A national digital recruitment campaign for the Phase 3 LIBREXIA-AF atrial fibrillation trial spent $163,949 across…
PREPRINTLongevity
80 MHz Benchtop NMR Quantifies Key Lipoproteins and Triglycerides in Serum, Reproducing Epidemiological Associations
A benchtop NMR spectrometer operating at 80 MHz — far less powerful than laboratory-grade 600 MHz instruments…
PREPRINTLongevity
12-Ward Australian Trial Tests Staff-Led Education to Cut Hospital Falls
A 65-week, 12-ward stepped-wedge cluster randomised controlled trial across five Australian hospitals will test…
Studies
Immunotherapy Adds No Quality-of-Life Benefit in Limited-Stage Small Cell Lung Cancer
For patients and clinicians weighing the trade-offs of adding immunotherapy to standard treatment in limited-stage…
Studies
CMR GUIDE Trial: ICD Implantation Neutral on Primary Arrhythmia Endpoint but Reduces SCD and Benefits Younger Patients with Mid-Range EF and Scar
Millions of heart disease patients fall into a diagnostic no-man's land — their cardiac function is too preserved to…
Studies
Pediatric Pneumonia Exam Findings Show Inconsistent Reliability Across Two Clinicians
When clinical guidelines steer physicians away from imaging and toward physical examination alone to diagnose…
Studies
Peroxisome Loss Corrupts Insulin Integrity and Destabilizes Beta Cell Identity
Glucose dysregulation is typically blamed on insufficient insulin — but what if the insulin itself is structurally…
Studies
Ferritinophagy Dysregulation Drives Iron-Mediated Injury Across Four Major Organs
Iron is a paradox in human biology — essential for life yet lethal in excess. A newly published review in Autophagy…
Studies
CT Coronary Angiography Identifies High-Risk Plaque Beyond Stenosis Severity
For patients arriving at emergency departments with chest pain, the difference between unnecessary hospitalization and…
Studies
Shortened Antibiotic Courses Match Standard 6-Week Regimen in Endocarditis Trial
For decades, the six-week antibiotic course for infective endocarditis has been more tradition than evidence — a…
Studies
GLP-1 Agonists and Bariatric Surgery Show Promise in Endometrial Cancer Management
Endometrial cancer incidence is rising in lockstep with global obesity rates, and in early-stage disease, women are…
Longevity
GLP-1 + Menopause HRT Combo for Weight Loss: Promising But Premature
An expert consensus from Spain's Menopause Society synthesized evidence on GLP-1 receptor agonists and dual incretin…
Fitness
Myonuclear Retention and DNA Methylation Encode Decades-Long Muscle Training Memory
Skeletal muscle encodes prior exercise history through at least six parallel molecular mechanisms: myonuclear…
Supplements
Melatonin's Prolactin Pathway May Link Long-Term Use to Heart Failure Risk
Melatonin is taken nightly by millions of adults who regard it as essentially harmless — a natural sleep aid with a…
Studies
NEJM Editorial Discusses SINGLE-AF Trial on Anticoagulation for Atrial Fibrillation with a Single Stroke Risk Factor
Atrial fibrillation affects tens of millions of adults globally, and the decision of when to start blood thinners sits…
Studies
CRISPR Liver Edit Sustains ANGPTL3 Suppression in Cardiovascular Risk Trial
Permanently rewriting a single gene in the liver to lower cardiovascular risk has long been a theoretical aspiration…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.