PREPRINTStudies
Genetics Show Higher BMI Raises HbA1c 0.26 SD in African Adults
Mendelian randomization using 363 BMI-associated variants with consistent effects across ancestries indicates that…
Nutrition
Intensive Na/K Feedback Program Cuts Salt Intake by 0.53 g/day in Japanese Communities
A post hoc regional analysis of Japan's Population-based Sodium/Potassium Improvement Program compared two Hokkaido…
Nutrition
Mediterranean Lifestyle Cuts Mortality 30–46% Across All Income Groups
In the prospective Lifelines cohort tracking 105,812 Dutch adults over a median 13.25 years, adherence to the MEDLIFE…
PREPRINTSupplements
10 µM Zinc Supplementation Extends Healthspan and Fights Protein Aggregation in Worms
In aging C. elegans, whole-body zinc levels fall by roughly 90% between day 1 and day 13 of adulthood. Supplementing…
PREPRINTWellbeing
CBT for Insomnia Improves Subjective Cognition but Not Brain Activity Over 1 Year
In a randomized controlled trial of 56 adults with insomnia disorder and 20 good sleepers, CBT for insomnia (CBTi)…
PREPRINTStudies
Early post-bariatric weight loss predicts 2-year but not long-term outcomes
Among 216 adults undergoing sleeve gastrectomy or Roux-en-Y gastric bypass, percentage total weight loss (%TWL) at 3…
PREPRINTWellbeing
Part-Time Work Into Your 70s Cuts Dementia Risk by 38%
Among 13,879 U.S. Health and Retirement Study participants, those who maintained sustained part-time employment…
PREPRINTSupplements
Vitamin D below 10 ng/mL doubles 10-year mortality risk in 412,000 adults
In a UK Biobank analysis of 412,020 adults with 31,197 deaths, seasonally normalized 25-hydroxyvitamin D [25(OH)D]…
Studies
Ketogenic Diet and Aerobic Exercise Top Rankings for PCOS Cardiometabolic Risk
A Bayesian network meta-analysis of 43 randomized controlled trials (2,433 participants) systematically compared…
Nutrition
16-Week Vegan Diet Cuts Liver Fat 33%, Restores Beta-Cell Function in T2D
A 16-week ad libitum low-fat vegan dietary intervention in 25 adults with type 2 diabetes produced striking metabolic…
Fitness
Higher Pre-Diagnosis VO2max Cuts Post-Cancer Mortality Risk by 29–59%
Among 10,462 UK Biobank participants who later developed cancer, higher cardiorespiratory fitness (CRF) at baseline…
Nutrition
Higher Plasma Omega-3 Linked to 20% Lower Mortality in 144,900 Adults
In the Mexico City Prospective Study — 144,900 adults followed for up to 24 years — higher circulating omega-3 fatty…
PREPRINTLongevity
Bone hormone osteocalcin reverses age-related locomotor decline via motoneuron mitophagy
The bone-derived hormone osteocalcin (OCN) acts on spinal motoneurons via the receptor GPR158 to regulate autophagy…
PREPRINTWellbeing
Year-Long Brain Implant Study Maps How Seasons and Weather Reshape Sleep
Continuous subcutaneous EEG recordings from 20 healthy adults across a full year reveal that sleep architecture is…
PREPRINTLongevity
Restoring noradrenaline-like signalling in fly neurons extends lifespan and reverses motor decline
In aging Drosophila brains, octopamine (the invertebrate equivalent of noradrenaline) normally drives glucose uptake…
PREPRINTLongevity
Higher Ambient UV Linked to 36,000 Fewer CV Deaths and 50,000 Fewer Cancer Deaths Annually in US
Across 704,808 annual cardiovascular deaths and 565,287 annual cancer deaths in US Health Service Areas, higher…
PREPRINTFitness
Sarcopenia Risk Linked to 44.6 mg/dL Higher Post-Meal Glucose Spike in Older Diabetics
In a cross-sectional study of 300 older Indian adults (mean age 67.6 years) with type 2 diabetes and controlled…
Nutrition
Pro-inflammatory diet nearly doubles MASLD mortality; antioxidant diet halves it
Among 3,048 U.S. adults with steatotic liver disease (2,146 MASLD, 902 MetALD) followed across the 2005–2018 NHANES…
Longevity
SGLT2i Cuts CKD Composite Risk 24% vs RAS Inhibitors in 36,000-Patient Study
In a propensity-score-matched cohort of 36,150 adults with moderate-to-severe CKD (eGFR 15–60 mL/min/1.73 m²)…
Fitness
Exercise Boosts Balance by 0.83 SMD in Osteoporosis: Dose Thresholds Identified
Pooling 13 randomized controlled trials, exercise interventions produced a statistically robust improvement in balance…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.