PREPRINTStudies
Nepal's Rural RHD Rate 6x Higher Than Kathmandu, Zero Decline in 30 Years
Pooled analysis of ten echocardiography-confirmed studies across Nepal — encompassing 209,815 participants and 5,440…
PREPRINTStudies
1-in-5 Nepalese Adults Have Metabolic Syndrome, But True Rate Could Be 2–79%
Pooling eight observational studies covering 21,708 Nepalese adults, this systematic review estimates metabolic…
PREPRINTStudies
Kratom and Ibogaine Show Alarming Cardiac Arrhythmia Signals in 18.5M FDA Reports
Across 18,499,626 FDA Adverse Event Reporting System cases from 2000–2024, two psychoactive substances stand out for…
Studies
GLP-1 Receptor Agonists Linked to Elevated Alopecia Risk Versus Rival Diabetes Drugs
As GLP-1 receptor agonists like semaglutide and tirzepatide reach tens of millions of users globally, questions about…
Studies
Maresin 1 Lipid Mediator Shrinks Jaw Bone Lesions via Immune Regulation
Chronic dental infections that quietly destroy jawbone affect hundreds of millions of people globally, yet treatment…
Studies
Seven ADC Targets Reshape Second-Line Small-Cell Lung Cancer Treatment Landscape
Small-cell lung cancer's brutal biology — rapid progression, early metastasis, and near-universal resistance to…
Studies
Mapped Resistance Mechanisms Signal New Era for Lung Cancer Immunotherapy
Immune checkpoint inhibitors transformed lung cancer treatment, yet most patients who initially respond eventually…
Studies
Genetic Risk Profiles for ADHD and ASD Shifted Over Three Diagnostic Decades
Rising ADHD and autism diagnoses have long been attributed to shifting awareness and diagnostic criteria — but a new…
Studies
AI Virtual Cell Model Predicts Drug Synergy Using 38 Million Protein Measurements
The prospect of testing thousands of drug combinations in a living tumor cell — without touching a single patient…
Longevity
Semaglutide Extends Female Mouse Lifespan Via Calorie-Restriction Pathways
Most GLP-1 drugs are prescribed for blood sugar and weight — but if their longevity effects in mammals generalize…
Studies
IL1RAP Blockade Unlocks Immune Response in Notoriously Treatment-Resistant Pancreatic Cancer
Pancreatic cancer remains one of oncology's most intractable challenges, with five-year survival rates stubbornly…
Longevity
Semaglutide Extends Lifespan in Aging Mice, Mimicking Calorie Restriction Mechanisms
The GLP-1 drug class has rapidly transformed metabolic medicine, but a fundamental question has lingered: are its…
Studies
Retinal AI Scan Stratifies Cardiovascular Risk Without Blood Tests
For the roughly one-third of adults who fall into cardiovascular risk's frustrating middle ground — not clearly…
Studies
GLP-1 Agonists Cut Psoriasis, HS, and Eczema Burden via Immune-Metabolic Pathways
Tirzepatide combination therapy in psoriasis patients achieved enhanced skin clearance alongside substantial weight…
Studies
Ambrisentan Blocks Doxorubicin Cardiotoxicity via p53/mTOR Mitochondrial Rescue
Pretreatment with ambrisentan, a selective endothelin A receptor antagonist approved for pulmonary arterial…
Longevity
β-Cell Senescence Shows Dual Role: Protective and Destructive in Endocrine Aging
Cellular senescence — the state of irreversible cell-cycle arrest — distorts endocrine communication through at least…
Studies
Ketamine Rewires Brain Waves Differently Across Three Treatment-Resistant Disorders
Ketamine's rapid antidepressant and anxiolytic effects have captivated clinicians for years, but a quiet assumption…
Studies
SCLC Molecular Subtypes Reframe How DLL3-Targeted Therapies Succeed or Fail
For decades, small cell lung cancer was considered a monolithic, uniformly lethal disease — one that simply didn't…
Studies
2.7 Billion Still Breathe Second-Hand Smoke Despite Three-Decade Decline
Population growth is quietly erasing decades of public health victories against tobacco exposure. Even as…
PREPRINTLongevity
Cheap Blood Ratio Predicts Deadly Lung-Vessel Phenotype in HFpEF Patients
Among 169 adults with HFpEF and invasively confirmed postcapillary pulmonary hypertension, higher…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.