Longevity
Spermidine Restores Hippocampal NPY Signaling Lost to Aging Autophagy Decline
Autophagy within hypothalamic NPY+/AGRP+ neurons governs hippocampal presynaptic active zone architecture and…
Longevity
FIGO/IMS Position Paper Calls for Reframing POI and Early Menopause as Chronic Endocrine Conditions
Premature ovarian insufficiency (POI) and early menopause (EM) dramatically compress the window of estrogen exposure…
Studies
4:3 Intermittent Fasting Trial Tests Weight Loss in Breast Cancer Survivors
Excess body weight after a breast cancer diagnosis is not merely a cosmetic concern — it measurably worsens recurrence…
Studies
TB Preventive Treatment Linked to Lower Incidence and Mortality in HIV Patients Across Six Nations
For the millions of people living with HIV in high-tuberculosis-burden settings, the gap between clinical trial…
Fitness
Web-Based Cardiac Rehab Program Reaches Rural Women With 82% Initiation Rate
Cardiac rehabilitation is one of the most evidence-backed interventions for reducing post-cardiac-event mortality, yet…
Studies
Intranasal mRNA Nanoparticles Bypass Blood-Brain Barrier, Restore Cognition in TBI Model
One of neuroscience's most stubborn engineering problems — how to deliver therapeutic molecules into the brain without…
Nutrition
Alcohol-Related Liver Disease Deaths Nearly Doubled Over Two Decades
One of medicine's most preventable killers is quietly accelerating. Alcohol-related liver disease now kills at nearly…
Wellbeing
Yemen's First Chronotype Survey Reveals Intermediate Sleep Patterns Dominate Young Adults
Understanding how circadian biology varies across underrepresented populations matters more than it might appear. Most…
Nutrition
GLP-1 Drug Cycling Linked to Lean Mass Loss and Metabolic Rebound Risk
The explosive adoption of GLP-1 receptor agonists has outpaced understanding of what happens when patients stop taking…
Studies
Sub-County Measles Modeling Reveals Hidden Epidemic Threshold Crossed After 2022
Standard public health surveillance may be missing a critical inflection point in measles risk. Most Americans assume…
Studies
AI Framework Decodes Colorectal Tumor Architecture to Predict Survival and Chemotherapy Benefit
For decades, pathologists have scrutinized tumor tissue under microscopes, relying on trained intuition to spot…
Longevity
Kidney as Inflammaging Hub: SASP, NLRP3, and Senolytic Prospects
Chronic kidney disease affects roughly 10% of the global population, yet its deep mechanistic entanglement with…
Nutrition
Oncology Nutrition Gaps Signal Case for Food-as-Medicine Integration in Cancer Care
Nutrition remains one of the most underutilized levers in cancer treatment, yet its influence on treatment tolerance…
Studies
Bangladesh WASH Coverage Gaps Persist Despite Decade of Sanitation Gains
Safe water and sanitation access is one of the most powerful — yet underappreciated — determinants of population…
Studies
Country-Specific AWaRe Antibiotic Estimates Validate 70% Global Access Target with Local Adjustments
Global antibiotic stewardship has long relied on broad targets, but a blunt percentage applied uniformly across vastly…
Supplements
Nine Years of Kratom Poison Center Data Reveal Rising Exposure Rates and ICU Risk
Kratom occupies an unusual regulatory gray zone — marketed as a botanical supplement, used for pain relief and opioid…
PREPRINTLongevity
England's Over-50s: Pain Up 27%, Memory Improves—A Fractured 20-Year Health Picture
Analysis of three waves of the English Longitudinal Study of Ageing—covering 8,389 (2004/05), 8,549 (2012/13), and…
PREPRINTNutrition
AI System Predicts 20-Year Mortality with 0.923 AUC Using NHANES Data
A hybrid web-based clinical decision support system called NutrIA, trained on harmonized NHANES data spanning…
PREPRINTStudies
133,718 ACS Patients: Ticagrelor vs. Prasugrel Show No Credible MACE Difference
A multinational retrospective cohort study across seven claims and EHR databases—ultimately drawing on 133,718 ACS…
PREPRINTLongevity
DNA Methylation Scores Predict Incident ASCVD With ~2× Hazard Ratio in 44,674 Veterans
In the largest epigenome-wide study of cardiovascular risk to date, three DNA methylation risk scores (MRS) derived…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.