PREPRINTStudies
Machine Learning Identifies Polypharmacy as Top Driver of Medication Burden
Random forest machine learning analysis of 390 ambulatory patients aged 65+ in Nepal identified polypharmacy and need…
Wellbeing
Poor Sleep in Atopic Dermatitis Patients Linked to Memory Dysfunction
Chronic skin inflammation may exact a hidden cognitive toll through disrupted sleep patterns, potentially affecting…
Fitness
European Arthritis Guidelines Elevate Exercise to Standard Care Protocol
Joint health management may be fundamentally shifting as European rheumatology experts formally position physical…
Longevity
Brain Preconditioning Activates NAD+/Sirtuin Pathways Against Stroke Damage
Brain preconditioning triggers three coordinated protective modules against stroke damage: rapid synaptic downscaling…
Longevity
Fasting Research Lacks Human Evidence Despite Promising Metabolic Pathways
University of Pittsburgh researchers conclude that while humans can survive months without calories and intermittent…
Longevity
DTI-ALPS Brain Imaging Predicts Aging, Blood Pressure Below 120 Associated With Reduced Brain Aging
Researchers developed a brain aging biomarker using DTI-ALPS imaging, which measures fluid flow along perivascular…
Longevity
Senescent Cell Clearance Ameliorates HFpEF in Mice by Targeting cGAS-STING-Driven Inflammation
Genetic elimination of senescent cells completely reversed heart failure with preserved ejection fraction (HFpEF) in…
Longevity
NVP-ADW742 IGF1R Inhibitor Extends Mouse Healthspan 93 Days Despite Toxicity Concerns
Two selective IGF1R inhibitors, picropodophyllin (PPP) and NVP-ADW742, demonstrated significant healthspan benefits…
Studies
Nine-Protein Blood Test Predicts Kidney Disease Risk in African Americans
A breakthrough in personalized kidney health monitoring could transform outcomes for millions of African Americans who…
Studies
Diagnostic Challenges Increase as Infectious Diseases Resurge Globally
The resurgence of previously controlled infectious diseases presents a diagnostic challenge that could complicate…
Wellbeing
Food Insecurity in Childhood Linked to Increased Weight Loss Attempts
The relationship between hunger and body image appears more complex than previously understood, with implications…
Wellbeing
Problem-Solving Training Reduces Depression in Young Cancer Patients
Cancer diagnosis between ages 18-39 creates a perfect storm of psychological vulnerability, occurring when young…
Wellbeing
Digital Interventions Show Promise for Reducing Childhood Anxiety Symptoms
Childhood anxiety disorders now affect unprecedented numbers of young people, creating urgent demand for accessible…
Studies
Small Molecule Design Reveals Two Pathways to Target Undruggable MYC Oncoproteins
Cancer researchers may finally have viable strategies to attack one of oncology's most elusive targets. The MYC…
Studies
Antibody-Based Apheresis Prolongs Pregnancy by Median 10 Days in Pilot Trial for Very Preterm Preeclampsia
Preeclampsia affects up to 8% of pregnancies worldwide and remains a leading cause of maternal and fetal mortality…
Studies
Apixaban Shows 54% Lower Bleeding Risk Than Rivaroxaban in Clot Treatment
Blood clot treatment decisions just became clearer for millions facing venous thromboembolism, as new evidence reveals…
Studies
Cardiovascular Health Metrics Cut Black-White Mortality Gap by 58 Percent
Optimizing cardiovascular health through eight key lifestyle factors substantially reduces racial disparities in heart…
Studies
Pulsed Field Ablation Shows 13% Silent Brain Lesion Rate in Atrial Fibrillation
Silent brain lesions represent an underappreciated complication of cardiac procedures that could accumulate over time…
Studies
Large-Scale Genetic Study Reveals 58 Anxiety Risk Variants, GABA Pathway Central
The genetic underpinnings of anxiety disorders have remained frustratingly opaque despite their massive burden on…
Studies
Glyphosate Herbicide Shows Stronger Cancer Links Through New Bone Sequestration Mechanism
The mounting evidence against the world's most widely used herbicide presents a sobering picture for the millions of…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.