Longevity
ADIOL Hormone Links Fasting Benefits to Neural Health via Kynurenine Pathway
Researchers identified 5-androstene-3β,17β-diol (ADIOL), a steroid hormone discovered nearly 100 years ago, as the…
Studies
Brain Cell Analysis Links 345 Genes to Six Mental Health Disorders
Mental health research has long struggled with a fundamental puzzle: how do thousands of genetic variants scattered…
Studies
Cystatin C Blood Marker Predicts Heart Failure Deaths Better in Reduced Ejection
Heart failure patients may soon have access to more precise prognostic tools through a simple blood test that measures…
Longevity
Brain Protein Cleanup Enzymes Decline With Age But Antioxidants Restore Function
The brain's ability to maintain proper protein function may deteriorate earlier in aging than previously recognized…
Studies
RNA-Based Therapies Show Promise for Genetically-Elevated Cardiovascular Risk Factor
Cardiovascular disease remains the world's leading killer despite decades of advances in cholesterol management…
Studies
Nine-Protein Blood Test Predicts Kidney Disease in APOL1 Carriers
Genetic predisposition to kidney disease just became more actionable. Adults carrying high-risk APOL1 gene…
Longevity
Global Fertility Rates Approach Replacement Threshold, Signaling Population Peak
The trajectory toward global population stabilization carries profound implications for aging societies and healthcare…
Studies
PCSK9 Gene Editing Shows Promise for Permanent Cholesterol Control
Permanent genetic modifications to lower cholesterol could revolutionize cardiovascular prevention, potentially…
Wellbeing
Review Positions CXCL13 as Key Hub in Multi-Organ Pathology of Obesity-Related Metabolic Inflammation
A critical immune signaling protein may explain why obesity triggers such widespread metabolic damage across multiple…
PREPRINTStudies
AI Model Identifies 29% More Cardiac Amyloidosis Cases Missed by Doctors
Researchers developed Amylo-Detect, a machine learning model that analyzes electronic health records to identify…
PREPRINTStudies
16.6% Medicare CLTI Patients Skip Vascular Imaging Before Major Amputation
Among 10,666 Medicare beneficiaries with chronic limb-threatening ischemia undergoing major lower-extremity…
PREPRINTWellbeing
CMR Guided ICD Placement Strategy Targets Ventricular Scar Detection
The CMR GUIDE trial protocol outlines a precision approach to preventing sudden cardiac death by using cardiac…
PREPRINTStudies
ECG Poor R-Wave Progression Shows No Independent Cardiovascular Risk
Analysis of 6,323 adults without baseline coronary artery disease found that poor R-wave progression (PRWP) on…
PREPRINTLongevity
Young Plasma Exchange Safely Replaces 16-26L Plasma Volume in MCI Patients with Alzheimer's Biomarkers
Researchers successfully replaced 16-26 liters of blood plasma from 12 mild cognitive impairment patients with plasma…
Longevity
Gut Microbiota and Vagus Nerve Drive Heart Fibrosis Through Myofibroblasts
This comprehensive review identifies how myofibroblasts expressing periostin, tenascin C, thrombospondin, and…
Longevity
GrimAge Epigenetic Clock Predicts 4-Fold Mortality Risk in HIV Patients
DNA methylation patterns in blood samples from 216 HIV patients with well-controlled infections revealed that specific…
Longevity
SIRT1 Emerges as Exercise-Induced Exerkine Targeting Multiple Aging Hallmarks
Exercise activates SIRT1 deacetylase across multiple organ systems including adipose tissue, hippocampus, heart…
Studies
Multiple Myeloma Survivors Face Triple Risk of Secondary Blood Cancers
Cancer survivorship increasingly demands attention to long-term complications that emerge years after initial…
Studies
Melanoma Tumors Hijack Cellular Communication Networks Through Extracellular Vesicles
The battle against melanoma may hinge on understanding how cancer cells weaponize the body's own messaging system…
Studies
Semaglutide Shows Promise for Psychiatric Conditions Despite Mood Concerns
Weight-loss medications may be poised to reshape psychiatric treatment in unexpected ways. Beyond its established…
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Health & Longevity Topics
Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.