Studies
Sirolimus Enhances Oncolytic Virus M1 Cancer Treatment Through Selective Tumor Replication
Cancer treatment could gain a powerful new combination as researchers discover how an existing immunosuppressive drug…
Studies
Phase 1 Trial: All-Oral Maintenance After RIC Transplant Yields 77% 2-Year Survival in Poor-Risk MDS/AML
Blood cancer patients facing the grimmest prognoses now have access to a potentially game-changing treatment approach…
Studies
Congo Basin Conflict Amplifies Zoonotic Disease Spillover Risk from 15 Pathogens
The intersection of armed conflict and ecological disruption creates unprecedented conditions for infectious disease…
Wellbeing
Healthcare Worker Ebola Training Deficits Reveal Critical Outbreak Response Gaps
Healthcare system resilience against emerging infectious diseases depends heavily on frontline worker preparedness…
PREPRINTLongevity
Tryptophan-Kynurenine Pathway Links Gut Bacteria to Heart Valve Disease
A study of 54 calcific aortic stenosis patients versus 41 controls reveals a focused gut-heart metabolic axis driving…
PREPRINTLongevity
Two MicroRNAs Drive Arterial Plaque Formation Through Macrophage Inflammation
This preprint identifies two microRNAs—miR487a-3p and miR6855-3p—as key drivers of atherosclerosis through their…
PREPRINTStudies
High-Frequency ECG Signals Show 0.56 Genetic Correlation With Heart Failure Risk
Advanced wavelet decomposition of 47,052 electrocardiograms uncovered 67 genetic loci associated with…
PREPRINTWellbeing
Exercise Stress Tests Reveal Hidden Heart Damage in Post-Pregnancy Women
Exercise stress echocardiography revealed distinct cardiovascular dysfunction patterns in 885 midlife women who…
PREPRINTLongevity
Statistical Plan Examines Lipoprotein(a) Levels as Aspirin Response Predictor
Researchers have outlined a statistical analysis plan to investigate whether lipoprotein(a) [Lp(a)] levels and…
Studies
Cancer Drug Magrolimab Triggers Red Blood Cell Destruction Through Immune Pathway
Cancer patients receiving targeted immunotherapy may face an unexpected challenge beyond tumor treatment: their…
Studies
EXO1 Enzyme Overexpression Triggers DNA Damage Even in Healthy Cells
Cancer prevention strategies may need fundamental revision following evidence that cells with intact DNA repair…
Studies
Blood Test Detects Protein Misfolding Before Alzheimer's Symptoms Appear
Early detection of neurodegeneration could transform preventive medicine, particularly given that recently approved…
Longevity
Gut Bacteria Show 84 Sex-Specific Links to Mobility Loss in Women
Analysis of 1,772 Hispanic adults aged 50+ revealed striking sex differences in how gut bacteria relate to mobility…
Studies
Fetal Surgery Technique Successfully Blocks Brain Blood Vessels in Lamb Study
A devastating brain vascular defect that kills or severely disables most affected newborns may soon be treatable…
Studies
CTNNA1 Gene Mutations Show Distinct Cancer Risk Patterns Versus CDH1
Understanding genetic cancer susceptibility just became more precise for families carrying specific inherited…
PREPRINTWellbeing
Global Leishmaniasis Risk Modeled 17% Higher Since 1990s in Climate Suitability Analysis
Machine learning analysis of global leishmaniasis distribution reveals a 17% increase in disease risk since the 1990s…
PREPRINTWellbeing
Some Japanese Communities Reach Up to 44.85% Dementia Supporter Coverage, Linked to Better Service Awareness
Analysis of 69 Japanese municipalities found communities with higher proportions of dementia supporter trainees…
PREPRINTLongevity
Circadian Disruption Linked to 0.21 nmol/L Lower Testosterone and 23% Higher Orchitis Risk in Large UK Biobank Study
Circadian rhythm disruption significantly impairs male reproductive health, with the lowest quartile of rest-activity…
PREPRINTStudies
Wearable Step Data Outperforms Self-Reports in Predicting 9 Health Outcomes
Researchers developed a standardized processing pipeline for Garmin step-count data and tested it in 67 older adults…
PREPRINTWellbeing
Left Atrial Stiffness Linked to Higher Mortality in Heart Failure Despite Improved Pumping
Researchers tracked left atrial stiffness index (LASI) trajectories in 1,039 heart failure patients receiving advanced…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.