PREPRINTStudies
CD36 Y325* Variant Drives 9% of Dilated Cardiomyopathy in African Ancestry
A nonsense variant in the CD36 gene (Y325*) accounts for 9% of dilated cardiomyopathy cases among individuals of…
Studies
Gut Barrier Breakdown Links Kidney Disease to Systemic Inflammation
The integrity of intestinal barriers emerges as a critical factor in chronic kidney disease progression, potentially…
Wellbeing
JAMA Review Finds Limited Mental Health Benefits from Cannabis
The widespread belief that cannabis effectively treats mental health conditions faces significant scientific scrutiny…
Longevity
GLP-1 Therapies Improve Heart Failure Symptoms Through Weight Loss, Inflammation Reduction
GLP-1 receptor agonists semaglutide and tirzepatide demonstrate measurable improvements in exercise capacity…
Studies
Tirzepatide Review Highlights GI Tolerability, Muscle Mass Monitoring Needs Amid Metabolic Benefits
Tirzepatide, targeting both GIP and GLP-1 receptors, demonstrates high rates of severe gastrointestinal events and…
Longevity
Senescent Cells Identified as Key Barrier to Muscle Recovery in Aging
Researchers identified multiple senescent cell populations—including vascular, stromal, and immune cells—that…
Longevity
AI Systems Analyze Multidimensional Biodata to Predict Healthy Aging Trajectories
AI systems now integrate genomics, epigenomics, proteomics, microbiome signatures, and digital biomarkers to detect…
Studies
Lipid Nanoparticles Successfully Target Heart Cells for Gene Therapy Delivery
Heart disease remains the leading killer globally, yet genetic medicines that could potentially reverse cardiac damage…
Studies
mRNA Platform Protects Against Multiple Deadly Ebola Virus Species
The next pandemic could emerge from any of several deadly Ebola virus species, yet current vaccines protect against…
Studies
Optical Tool Enables Precise Brain Capillary Damage Study for Aging Research
Understanding how individual blood vessel failures accumulate into cognitive decline has been nearly impossible to…
Wellbeing
Brain's Reward Benchmark System Associated with Depression Severity
The way your brain sets expectations for rewards may fundamentally determine your vulnerability to depression. This…
Longevity
Mitochondrial Protein Interactions Control DNA Repair Helicase Function
Mitochondrial DNA maintenance becomes increasingly critical as we age, with defective repair mechanisms linked to…
Studies
RNA Gene Variants Shape Temperature Adaptation Circuits in Worms
Temperature adaptation represents one of life's fundamental challenges, determining where species can survive and…
Studies
AI Models Predict Extensive Protein-Carbohydrate Interactions Across Proteomes
The intricate dance between proteins and carbohydrates in human cells has remained largely hidden until now, limiting…
Studies
Game Theory Model Reveals How Biological Cooperation Overcomes Evolutionary Selfishness
Understanding how cooperation emerges in biological systems has profound implications for human health, from cellular…
Studies
Lab-Grown Human Tissues Show Extraordinary Shape-Shifting Without Breaking
The human body's ability to stretch, bend, and reshape during development while maintaining structural integrity has…
Studies
Light-Activated Tissue Mapping Preserves Cellular Architecture During Molecular Analysis
Tissue analysis just gained a powerful new dimension that could transform how researchers study disease progression…
Longevity
Morphogen Gradient Scaling Reveals Key Mechanisms Behind Proportional Development
Proportional development—how organisms maintain proper body patterns regardless of final size—represents one of…
Studies
AI Models Using Patient Surveys Predict Cancer Care Needs 27% Better
Cancer survivors face unpredictable health crises that strain both patients and healthcare systems, yet current risk…
Studies
Systematic Review Links Coal Operations to Increased Cancer Risk Across Residential and Occupational Settings
The timing of this comprehensive analysis creates a stark contradiction with current energy policy directions. As the…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.