PREPRINTLongevity
Two MicroRNAs Drive Arterial Plaque Formation Through Macrophage Inflammation
This preprint identifies two microRNAs—miR487a-3p and miR6855-3p—as key drivers of atherosclerosis through their…
PREPRINTStudies
High-Frequency ECG Signals Show 0.56 Genetic Correlation With Heart Failure Risk
Advanced wavelet decomposition of 47,052 electrocardiograms uncovered 67 genetic loci associated with…
PREPRINTWellbeing
Exercise Stress Tests Reveal Hidden Heart Damage in Post-Pregnancy Women
Exercise stress echocardiography revealed distinct cardiovascular dysfunction patterns in 885 midlife women who…
PREPRINTLongevity
Statistical Plan Examines Lipoprotein(a) Levels as Aspirin Response Predictor
Researchers have outlined a statistical analysis plan to investigate whether lipoprotein(a) [Lp(a)] levels and…
Studies
Cancer Drug Magrolimab Triggers Red Blood Cell Destruction Through Immune Pathway
Cancer patients receiving targeted immunotherapy may face an unexpected challenge beyond tumor treatment: their…
Studies
EXO1 Enzyme Overexpression Triggers DNA Damage Even in Healthy Cells
Cancer prevention strategies may need fundamental revision following evidence that cells with intact DNA repair…
Studies
Blood Test Detects Protein Misfolding Before Alzheimer's Symptoms Appear
Early detection of neurodegeneration could transform preventive medicine, particularly given that recently approved…
Longevity
Gut Bacteria Show 84 Sex-Specific Links to Mobility Loss in Women
Analysis of 1,772 Hispanic adults aged 50+ revealed striking sex differences in how gut bacteria relate to mobility…
Studies
Fetal Surgery Technique Successfully Blocks Brain Blood Vessels in Lamb Study
A devastating brain vascular defect that kills or severely disables most affected newborns may soon be treatable…
Studies
CTNNA1 Gene Mutations Show Distinct Cancer Risk Patterns Versus CDH1
Understanding genetic cancer susceptibility just became more precise for families carrying specific inherited…
PREPRINTWellbeing
Global Leishmaniasis Risk Modeled 17% Higher Since 1990s in Climate Suitability Analysis
Machine learning analysis of global leishmaniasis distribution reveals a 17% increase in disease risk since the 1990s…
PREPRINTWellbeing
Some Japanese Communities Reach Up to 44.85% Dementia Supporter Coverage, Linked to Better Service Awareness
Analysis of 69 Japanese municipalities found communities with higher proportions of dementia supporter trainees…
PREPRINTLongevity
Circadian Disruption Linked to 0.21 nmol/L Lower Testosterone and 23% Higher Orchitis Risk in Large UK Biobank Study
Circadian rhythm disruption significantly impairs male reproductive health, with the lowest quartile of rest-activity…
PREPRINTStudies
Wearable Step Data Outperforms Self-Reports in Predicting 9 Health Outcomes
Researchers developed a standardized processing pipeline for Garmin step-count data and tested it in 67 older adults…
PREPRINTWellbeing
Left Atrial Stiffness Linked to Higher Mortality in Heart Failure Despite Improved Pumping
Researchers tracked left atrial stiffness index (LASI) trajectories in 1,039 heart failure patients receiving advanced…
Studies
Cancer Drug Osimertinib Disrupts Heart Muscle Through GATA4-MYLK3 Pathway
A breakthrough in understanding why a highly effective lung cancer medication causes heart problems could transform…
Wellbeing
Global Mental Disorder Cases Rise 95.5% to 1.17 Billion by 2023
Global mental disorder cases reached 1.17 billion in 2023, representing a staggering 95.5% increase from 1990 levels…
PREPRINTStudies
Non-English Heart Failure Patients Receive 33-Word Shorter Medical Histories
Among 552 heart failure patients, those whose primary language wasn't English received significantly abbreviated…
PREPRINTStudies
MMP-2 Biomarker Dominates Machine Learning Models Predicting Heart Attack Severity
Machine learning analysis of 152 heart attack patients revealed that just three biomarkers can achieve 94% accuracy in…
PREPRINTStudies
Resting Heart Rate Predicts Non-Cardiovascular Death in Adults Under 50
Among 3,291 adults aged 20-49 followed for nearly 18 years, each 10-beat-per-minute increase in resting heart rate…
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