Wellbeing
GLP-1 Drugs Show Anti-Inflammatory Effects Beyond Weight Loss in Skin
GLP-1 receptor agonists like semaglutide and tirzepatide suppress pro-inflammatory cytokine signaling while promoting a…
Studies
GLP-1 Drugs Show Anti-Inflammatory Properties for Gum Disease Treatment
Preclinical evidence reveals GLP-1 receptor agonists possess anti-inflammatory, antioxidative, and immunomodulatory pro…
Studies
Semaglutide 2.4mg Achieves 13.6kg Weight Loss in Prediabetes Network Analysis
A comprehensive Bayesian network meta-analysis of 55 randomized trials involving 16,610 prediabetic adults reveals that…
Wellbeing
Social Isolation Linked to Cortisol-Oxytocin Imbalance Associated with Cardiovascular Disease Risk
Social disconnection affects 16-25% of adults and creates a cortisol-oxytocin hormonal imbalance that directly damages…
Longevity
Klebsiella aerogenes bacteria drive sepsis severity through histamine-autophagy pathway
Aged sepsis patients harbor increased levels of Klebsiella aerogenes bacteria that produce histamine through a histidin…
Wellbeing
Former Prisoners Show 4-Fold Higher Mental Health Service Use Than Matched General Population Post-Release
Scottish administrative data tracking all 2015 prison releases reveals formerly incarcerated individuals access mental…
Studies
Methylene Blue Light Treatment Eliminates Drug-Resistant Pediatric Appendicitis Bacteria
Methylene blue activated by 665nm laser light achieved a 5.86 log reduction in E. coli bacteria isolated from children…
Longevity
GLP-1 Receptor Agonists Show Promise as 'Pharmacological Exercise' Against Neurodegeneration
GLP-1 receptor agonists like semaglutide and liraglutide demonstrate multiple neuroprotective mechanisms in preclinical…
Fitness
Resistance Training Reduces Brain Age by 2.3 Years in Adults
Resistance training reversed functional brain aging by 1.4 to 2.3 years in healthy adults, based on brain clock models…
Longevity
Surgery-Induced Cognitive Decline Shares Alzheimer's Pathways in Elderly
Postoperative cognitive dysfunction affects elderly surgical patients through neuroinflammation, blood-brain barrier di…
Supplements
Dual Polyphenol Micelles Achieve >98% Encapsulation Efficiency for Resveratrol and Rutin, Promising for Improved Bioavailability
Scientists engineered micelles that simultaneously deliver resveratrol and rutin with over 98% encapsulation efficiency…
Longevity
Resveratrol Stabilizes PER2 Clock Protein in Fetal Heart Cells
Resveratrol increases stability of the PER2 clock protein in both fetal cardiomyocytes and cardiac fibroblasts, shiftin…
Studies
Polyphenol-Porphyrin Nano-Aggregates Achieve 51.1% Photothermal Conversion for Wound Healing
Researchers engineered nano-aggregates combining natural polyphenols (resveratrol and piceatannol) with porphyrin photo…
Longevity
Review Links Obesity and Gut Dysbiosis to Alzheimer's Neuroinflammation via Blood-Brain Barrier Disruption
Obesity triggers chronic systemic inflammation that compromises the blood-brain barrier and primes brain microglia towa…
Nutrition
Gut Bacteria Transform Soy Compounds Into Bioactive Health-Promoting Molecules
Gut microbes actively transform soy-derived compounds into bioactive molecules that influence host physiology, while so…
Longevity
Prevotella corporis Bacteria Activates Hsp70 Protection Against Protein Aggregation
Prevotella corporis, a specific gut bacterium, uniquely activates the host's heat shock response and induces Hsp70 mole…
Studies
Cesarean Section Infections Affect 3-15% Despite Modern Prevention Protocols
Post-cesarean surgical site infections affect 3-15% of the 21% of global births delivered by C-section, creating a subs…
Fitness
Ten-Hour Eating Window Plus Resistance Training Cuts 3.2kg Fat
A controlled trial of 54 overweight college students found that combining 10-hour daily eating windows with resistance…
PREPRINTStudies
Air Pollution Associated with 14% Higher Dementia Risk Mainly Through Direct Pathways
Analysis of UK Biobank data revealed that highest exposure to PM2.5 fine particulate matter increases dementia risk by…
PREPRINTLongevity
AI Reveals Over 90 New HFpEF Genetic Loci, Identifies 11 Therapeutic Targets
A multimodal machine learning system called TRIAD-HFpEF identified over 90 novel genetic loci associated with heart fai…
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