PREPRINTLongevity
CYP11B2 C-allele Associated with 6-Fold Higher Hypertension Odds in Ghanaian Cohort
The CC genotype of the CYP11B2 rs1799998 (T-344C) promoter polymorphism carried a 6.35-fold greater odds of…
PREPRINTLongevity
Preliminary Analysis: GLS Cut-Off of -17% Shows 0.89 AUC for Identifying Reduced LVEF by CMR
A secondary diagnostic accuracy analysis of 34 patients found that a global longitudinal strain (GLS) cut-off of…
PREPRINTLongevity
Self-Supervised ECG AI Predicts Death Risk Across 6 Independent Cohorts
A self-supervised transformer model trained on over 7.2 million ECGs quantifies how difficult it is to reconstruct a…
Longevity
Italy's 16-Year Healthspan Gap Demands Systemic Longevity Medicine Overhaul
Italy's demographic profile is stark: 24.1% of its population is aged ≥65 — the EU's highest — yet healthy life years…
Studies
Second-Trimester Air Pollution Exposure Linked to 48–64% Higher Odds of Low Apgar Score
Newborn vitality at birth is a compressed snapshot of everything that happened in the womb — and mounting evidence…
Studies
LIG1 Loss Marks TNBC Tumors Vulnerable to Olaparib-Ceralasertib Combination
Triple-negative breast cancer remains among the most treatment-resistant malignancies precisely because it lacks the…
Wellbeing
Hypoglossal Nerve Stimulation Linked to Lower Cardiovascular Risk in Sleep Apnea
For the roughly 30 million Americans with obstructive sleep apnea who cannot tolerate CPAP, the cardiovascular…
Studies
Wildfire Smoke Associated with 18% Higher NYC Elementary School Absences
As wildfire seasons grow longer and smoke plumes increasingly blanket distant cities, the health burden extends well…
Studies
Triple-Reporter Mouse Model Tracks Tumors Across Whole-Body to Cellular Scale
Understanding how cancers evolve, spread, and respond to treatment has long been constrained by the limitations of…
Studies
Large Prenatal Acetaminophen Study Links Use to Lower Large-for-Gestational-Age Risk
For millions of pregnant individuals who reach for acetaminophen to manage pain or fever, the question of fetal safety…
Studies
Tau Deposits Impair Cognition in PSP Via Remote Cortical Network Connections
For decades, the assumption in neurodegenerative disease research has been that brain damage causes dysfunction where…
Nutrition
Invasive E. coli Pathobionts Promote Colorectal Cancer Stemness via Hippo Pathway in Apc(Min/+) Model
The assumption that colorectal cancer is primarily a genetic disease is being steadily dismantled by microbiome…
Longevity
Engineered Enzyme Reverses Irreversible Glycation Damage in Aged Human Tissue
For decades, a core assumption in aging biology held that certain molecular scars accumulate irreversibly — that once…
Studies
Bayesian EHR Model Uncovers 21 Replicable Disease Signatures Across 683,000 Patients
Most disease risk models treat conditions as isolated events — a myocardial infarction here, a diabetes diagnosis…
Studies
Computational Framework Reveals How Analysis Choices Shape Synaptic Plasticity Interpretations
How the brain encodes memories at the cellular level depends critically on the physical shape of dendritic spines…
Wellbeing
RBFOX1 Splicing Gene Acts as Central Hub Linking Depression, Anxiety, and Neuroticism
Understanding why major depression so frequently travels alongside anxiety, irritability, and neurotic personality…
Supplements
Natural Compounds Reveal Dual Molecular Targets for Obesity and Fatty Liver Disease
As the global burden of metabolic disease accelerates, the pharmaceutical pipeline for fatty liver disease remains…
Nutrition
Gut Microbiome Shields Glial Cells From Tau and Amyloid Accumulation in Fly Model
The gut-brain axis may be more central to Alzheimer's disease progression than previously recognized. If microbial…
Studies
GLP-1 Drugs Linked to Rare Optic Nerve Injury Amid Mixed Retinal Data
As semaglutide and its GLP-1 receptor agonist relatives become among the most widely prescribed drugs on the planet…
Studies
Tau Deposits Linked to Remote Cortical Network Disruption and Cognitive Decline in PSP
For anyone tracking neurodegeneration research, the assumption has long been that brain damage causes symptoms where…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.