Wellbeing
Pupil Diameter and Skin Conductance Predict Cognitive Engagement with Linear Model
For the more than one-third of neurofeedback participants who never learn to regulate their own brain activity, the…
Longevity
ARDD 2025: Aging Field Pivots From Description to Engineered Longevity Interventions
For decades, aging research catalogued what goes wrong in aging bodies. The 2025 Aging Research and Drug Discovery…
Studies
Dual Immune Checkpoint Crosstalk in Glioblastoma Opens Combination Therapy Pathways
For patients facing glioblastoma — one of oncology's most treatment-resistant cancers — understanding why immune…
Studies
Casdatifan Targets HIF-2α in Kidney Cancer With Once-Daily Oral Dosing
For the roughly 75,000 Americans diagnosed with kidney cancer annually, treatment options for the most common subtype…
Studies
Global Mental Disorder Burden Tracked Across 204 Nations Over Three Decades
Mental health conditions now represent one of the most consequential sources of disability worldwide, yet their true…
Studies
Soft Robotic Heart Simulator Replicates Valve Disease for Surgical Testing
Every year, millions of patients undergo cardiac procedures for valvular disease, yet surgeons and engineers…
Studies
Coercive Practices and Structural Discrimination Still Dominate Global Psychosis Care
For the hundreds of millions living with psychosis worldwide, the gap between international human rights standards and…
Studies
15-Amino-Acid Switch Autonomously Controls CAR-T Exhaustion and Potency
CAR-T cell therapies have transformed oncology, yet two stubborn biological barriers — T cell exhaustion from chronic…
Wellbeing
AI Chatbot Adjunct to Group CBT Shows Feasibility for Student Anxiety
Campus mental health services are chronically under-resourced, leaving millions of students without timely support…
Nutrition
Oat Avenanthramides Cut 12-LOX/12-HETE Inflammatory Axis, Restoring PCOS Hormones
Avenanthramides (AVAs) extracted from oats (Avena sativa) dose-dependently suppressed the 12-lipoxygenase (12-LOX)…
Supplements
Resveratrol Alleviates High-Fat Diet–Induced Obesity and Is Associated with Activation of β3-AR/AMPKα-Related Thermogenic Signaling in Mice
In HFD-induced obese mice, resveratrol (RSV) supplementation reduced body weight gain, improved glucose tolerance…
Longevity
4 Skin Microbes Predict Age Group with 0.97 AUC Accuracy
A pilot study of 80 healthy Chinese participants across four age cohorts (centered at 10, 30, 50, and 70 years) mapped…
Nutrition
54 Cohorts, 1.8M People: Each Mediterranean Diet Point Cuts Death Risk 4%
Pooling 54 prospective and retrospective cohort studies encompassing 1,833,267 participants and 346,034 deaths, this…
Supplements
Spermidine Restores RANKL/OPG Balance, Cuts Bone Loss in Steroid Osteoporosis
At 20 mg/kg co-administered with dexamethasone (7 mg/kg IM weekly for 5 weeks) in a rat model, spermidine reversed key…
Supplements
Daily Probiotics Slow Telomere Shortening in Adults Over 60 in RCT
In a randomized, double-blind, placebo-controlled substudy of the PROBIOSENIOR trial, 46 adults aged 60+ received…
Longevity
NAD+ Depletion and NAMPT Activation in Cardiovascular Disease: Review of Mechanisms and Therapeutic Potential
Cardiac NAD+ depletion creates a cascade of mitochondrial dysfunction, elevated reactive oxygen species, and…
Longevity
Senescent T Cells Accumulate at Gut Epithelium in Aged Mice, Linked to Mucosal Immune and Metabolic Changes
Spatial proteomics applied to murine colonic mucosa reveals a coordinated cluster of age-associated molecular…
Longevity
Review Maps Senolytics Like Dasatinib+Quercetin Against Ovarian SASP Pathways in Preclinical Models
Ovarian aging accelerates through cellular senescence cascades: primordial follicle depletion, SASP-driven stromal…
Supplements
Ginsenoside Rg1 and Exercise-Induced Muscle Damage: A Narrative Review of Senolytic and Regenerative Mechanisms
Ginsenoside Rg1, the steroidal saponin constituent of Panax ginseng, stands alone among ginsenosides as the only…
Studies
MRI Texture Features in Hippocampal Subfields Associated with Alzheimer's Severity and Cognition
For decades, brain imaging in Alzheimer's research has relied on volume measurements — how much the hippocampus…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.