Longevity
IL-11 Cytokine Drives Ovarian Stiffening—Blocking It Reverses Aging Markers
For millions of women, ovarian aging arrives earlier and more aggressively than any other organ system's decline…
Studies
Cannabis Cessation Apps Score Poorly on Evidence-Based Quality Standards
As cannabis use climbs globally and treatment demand outpaces clinical capacity, digital tools have been positioned as…
Longevity
Network Medicine Maps Aging Hallmarks to Repurposable Drug Candidates
The prospect of extending healthy human lifespan without developing entirely new pharmaceuticals just became more…
Studies
Enteric Disease Deaths Fall by Nearly Two-Thirds Since 1990, But Burden Remains High
For parents of young children in low-income regions and global health advocates, this massive epidemiological…
Longevity
IL-11 Inhibition Reverses Ovarian Fibrosis and Restores Fertility in Aged Mice
Ovarian aging quietly undermines both reproductive health and broader hormonal balance in women long before menopause…
Wellbeing
677-Study Review Maps Where AI Mental Health Tools Fall Short
Mental health care faces a global access crisis — too few providers, too much stigma, and too little scalability. The…
Studies
AI Adoption in Drug Safety Testing Accelerates Despite Widespread Implementation Gaps
Every drug that reaches a human clinical trial first passes through a gauntlet of preclinical safety tests designed to…
Fitness
Six Decades of European Youth Fitness Data Reveal Alarming Declining Trends
Youth fitness trajectories serve as a leading indicator of population health decades before chronic disease burdens…
PREPRINTStudies
AI Model Automates Key Echo Parameters (VTI, Atrial Areas) With R² Up to 0.88 Across Multi-Cohort Datasets
Trained on 186,712 sonographer-annotated echocardiographic images from 93,978 studies across 56,855 patients at…
PREPRINTLongevity
Blood miRNA miR-664a-3p Associated with Coronary Plaque Burden in Small Indian Study (AUC 0.84-0.88)
A blood-based microRNA signature may reveal coronary plaque instability without invasive imaging. In two independent…
PREPRINTLongevity
High Urinary Na/K Ratio Doubles Brain White Matter Lesion Odds in Older Adults
Among 296 community-dwelling Japanese adults (mean age 68.7), those in the highest quartile of 24-hour urinary…
PREPRINTFitness
6-Minute Walk Distance Links to Episodic Memory in Sedentary Adults Over 70
Among 58 sedentary, cognitively unimpaired older adults (mean age 70.7 years, 84.5% female), greater 6-minute walk…
PREPRINTWellbeing
Dementia Patients Back AI Medication Reviews—With Key Conditions Attached
Among 12 people living with dementia (PLwD) and 14 carers recruited across two focus groups, qualitative interviews…
Longevity
GLP-1 Agonists, SGLT-2 Inhibitors & VLEKT: Narrative Review Maps Potential Targets in Obesity's Four Key Complications
Obesity's cardiometabolic cascade operates through four converging pathways: upper-airway collapsibility driving OSAS…
Studies
GLP-1 Agonists in Breast Cancer: Attenuated Weight Loss, Survivorship Signals Emerge
Breast cancer patients using GLP-1 receptor agonists (GLP-1RAs) achieve meaningful but measurably smaller weight…
Longevity
Circadian Clock Collapse in CKD: Melatonin's 6-Pathway Renoprotective Case
In chronic kidney disease, retained uremic toxins and sustained NF-κB activation actively suppress the kidney's…
Longevity
Advances in Sarcopenia Management: Exercise, Nutrition (1.2–1.5 g/kg Protein), and Emerging Pharmacotherapies like Bimagrumab and Metformin
Sarcopenia management is converging on a multi-modal clinical framework, with protein thresholds of 1.2–1.5 g/kg/day…
Nutrition
Review: Balanced EAAs + Resistance Training May Promote PGC1-α-Independent Mitochondrial Biogenesis and Muscle Remodeling
Essential amino acids (EAAs) consumed in the post-absorptive state—not just peri-workout—drive mitochondrial…
Fitness
BDNF, IGF-1, and Cerebral Flow: How Exercise Reshapes the Aging Brain
Among community-dwelling adults over 60 — a population facing a 4.5% annual cumulative incidence of depression…
Fitness
Exerkines BDNF and VEGF Link Exercise Directly to Brain Neuroprotection Mechanisms
Physical inactivity constitutes a measurable risk factor for neurodegeneration, with exercise triggering release of…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.