Studies
Single-Cell Atlas Maps Huntington's Stage-Specific Corticostriatal Collapse in Mice
Understanding why specific neurons die in Huntington's disease — and precisely when their molecular identity begins to…
Longevity
cGAS Deletion Shortens Lifespan by Unleashing Transposon Activity and Epigenetic Chaos
A foundational assumption in longevity research — that suppressing the cGAS–STING inflammatory pathway would extend…
Studies
Xylitol May Disrupt Cancer Metabolism via Mitochondrial and Microbiome Pathways
The conventional view of cancer metabolism as broken mitochondria has given way to a more nuanced picture — one where…
Studies
ARIMA Outperforms Neural Networks in Forecasting Ghana Perinatal Mortality Trends
For health systems in sub-Saharan Africa, the ability to predict perinatal mortality months in advance could redirect…
Studies
Elevated Lp(a) Raises MI Risk 23% But Doesn't Amplify Evolocumab Benefit
Cardiovascular risk stratification is entering a new era of precision, and lipoprotein(a) sits at its center — yet…
Studies
Shingles Reactivation Under JAK Inhibitors May Amplify Cardiovascular Risk
A mechanistic gap in our understanding of why JAK inhibitors carry elevated cardiovascular risk may be partly filled…
PREPRINTLongevity
Diastolic Dysfunction and Atrial Remodeling Associated With Exercise Limits in Repaired Tetralogy of Fallot
In adults with repaired tetralogy of Fallot (rTOF) and preserved left ventricular ejection fraction (≥50%), reduced…
PREPRINTLongevity
19-Protein Plaque Signature Outperforms Histopathology in Distinguishing Symptomatic Atherosclerosis
Deep proteomic profiling of 88 carotid endarterectomy patients (51 symptomatic, 37 asymptomatic) using the Olink…
PREPRINTLongevity
Statin Exposure Linked to ~20% Lower AMI Risk in Adults ≥75 Without Prior CVD (Observational Study)
Among 174,014 community-dwelling adults aged 75 and older without prior cardiovascular disease, baseline statin…
PREPRINTLongevity
Rural Young Adults Face 28% Higher In-Hospital Death Risk from Heart Failure
Among 79,258 heart failure hospitalizations in adults aged 18–45 drawn from the National Inpatient Sample (2016–2022)…
PREPRINTLongevity
22–34% Higher Parietal/Occipital Blood Flow Linked to Cognitive Resilience in Amyloid-Tau+ Adults
Among 500 adults (mean age 67, 68% female) carrying both amyloid-beta and tau pathology confirmed by PET imaging…
Studies
GLP-1 Weight Loss: 60% Report Skin Laxity, Hair Loss, Muscle Weakness
Among 1,226 patients on pharmacologic weight management via a telemedicine platform, over 60% reported clinically…
Studies
Pan-European Survey Shows Fragmented GLP-1RA Adoption in OSA Care Despite SURMOUNT-OSA Trial Results
A pan-European survey across 24 sleep centres in 14 countries reveals that tirzepatide and other GLP-1 receptor…
Nutrition
8 Dietary Patterns Associated with 23–34% Lower Post-Heart Attack Death Risk in Observational Study
Among 5,895 MI survivors tracked for nearly 16 years across the Nurses' Health Study and Health Professionals…
Longevity
Epigenetic Clocks Show Accelerated Aging in Normal-Adjacent Colorectal Mucosa Near Tumors
Epigenetic age acceleration — measurable via DNA methylation clocks — is detectable not only in colorectal tumors but…
Longevity
DAF-2 Receptor Deletion Extends Male C. elegans Lifespan 440% via Sex-Specific IGF-1 Mechanisms
Ubiquitous degradation of the DAF-2/IGF-1 receptor in male Caenorhabditis elegans extends median lifespan by over 440%…
Studies
Central Adiposity Index Links to 23% Higher Asthma Odds in Youth
Childhood asthma management has long focused on triggers like allergens and air quality, but the metabolic…
Studies
Sodium Bicarbonate During Cardiac Arrest Shows No Benefit in Large Trial
For decades, emergency teams have routinely administered sodium bicarbonate during cardiac arrest to counter the…
Studies
Sodium Bicarbonate Shows No Survival Benefit in Hospital Cardiac Arrest Trial
For decades, sodium bicarbonate has been routinely administered during cardiac arrest under the assumption that…
Studies
Sodium Bicarbonate Shows No Survival Benefit in Cardiac Arrest RCT
For decades, sodium bicarbonate has been administered during cardiac arrest resuscitation based on physiological logic…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.