Studies
Plexin-B1 Gene Regulates Amyloid Plaque Architecture and Microglia Response
Plexin-B1, a gene traditionally known for guiding axon growth during neural development, actively shapes the glial cell…
Studies
Synaptic Protection Drug Demonstrates Safety Profile in Alzheimer's Patients
An experimental therapeutic designed to enhance synaptic resilience has cleared initial safety hurdles in Alzheimer's p…
Wellbeing
Monthly Cash Payments Preserve Memory Function in Aging Adults
Monthly cash payments of approximately $20 preserved cognitive function and reduced dementia risk among adults aged 40-…
Wellbeing
End-of-Life Planning Programs Show Unexpected Care Burden Increase
A comprehensive advance care planning program successfully increased documentation rates of patient preferences by 23%…
Longevity
Protein Misfolding Linked to Aging Through Shared 'Core Insoluble Proteome' in Worm Models
The Lithgow laboratory at Buck Institute has identified how misfolded proteins create cascading cellular dysfunction th…
Studies
Medicare Analysis Uncovers 5.3 Million Cases of Undetected Dementia
Analysis of Medicare claims data identified approximately 5.3 million beneficiaries with probable Alzheimer's disease o…
Longevity
New Projections Show Dementia Risk Hits 42% After Age 55
National Institute on Aging researchers project that individuals reaching age 55 today face a 42% lifetime probability…
Nutrition
8-Hour Eating Windows Produce Equal Weight Loss Regardless of Timing
European adults with obesity achieved comparable weight reductions and metabolic improvements whether they confined eat…
Longevity
In Female Mice, Maternal X Chromosome Bias Accelerates Brain Cell Aging and Memory Decline
X-chromosome inactivation patterns inherited from mothers appear to selectively disable critical neuronal genes, trigge…
Longevity
Dasatinib-Quercetin Senolytic Therapy Shows Subtle Bone Marker Changes but No Overall Bone Density Improvements in Postmenopausal Women
A placebo-controlled trial testing dasatinib plus quercetin in postmenopausal women with low bone density revealed marg…
Longevity
New Mouse Model Maps Inflammation Pathways Driving Multi-Organ Aging Decline
NIA researchers created a novel mouse model that captures the cascade of inflammatory processes underlying simultaneous…
Wellbeing
White Matter Hyperintensities Emerge as Modifiable Alzheimer's Risk Markers
White matter hyperintensities—bright lesions visible on brain MRI scans originating from small vessel damage—demonstrat…
Wellbeing
Financial Missteps Precede Dementia Diagnosis by Several Years
Payment delinquencies on mortgages and credit cards emerge as measurable indicators of cognitive decline occurring year…
Research
In This Issue
The latest issue of the Proceedings of the National Academy of Sciences (PNAS) covers a range of scientific topics. The…
Longevity
Big Data Analysis of the Exposome to Identify Factors Affecting Aging
Computational approaches are now dissecting the exposome — the totality of environmental influences from pollutants to…
Wellbeing
Loneliness Linked to 31% Higher Dementia Risk in Multi-Cohort Analysis
Analysis of multiple National Institute on Aging population cohorts reveals that subjective loneliness correlates with…
Wellbeing
Gut Microbiome Dysbiosis Linked to Neurodegeneration Risk via Inflammatory Pathways in Emerging Animal Research
Microbial imbalances in the intestinal tract appear to trigger cascading inflammatory responses that contribute to the…
Longevity
Buck Institute Analysis Tool Reveals New Cellular Aging Mechanisms
A computational analysis platform originally developed in 1998 has enabled researchers to decode previously hidden cell…
Longevity
Buck Institute Highlights Reproductive Biology Hub for Female Aging Research
The Buck Institute has established a dedicated Reproductive Biology Hub to investigate how female reproductive biology…
Longevity
Cancer Drug Screen Reveals Unexpected Kidney Stone Prevention Pathway
A compound initially identified in cancer drug screening has demonstrated dual efficacy against Huntington's disease pa…
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Health & Longevity Topics
Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.