PREPRINTNutrition
Fermentable Fiber Cuts Uremic Toxins IS and pCS in Kidney Disease Patients
A systematic review and meta-analysis pooling 13 randomized clinical trials (511 participants) and 15 controlled…
Wellbeing
Storytelling RCT Cuts Bereavement Anxiety in Dementia Family Caregivers
Bereavement after caregiving for a loved one with dementia carries a distinct psychological burden — one layered with…
Studies
Artemisinin Resistance Markers Emerging in East African Hotspots, Spatiotemporal Study Maps Prevalence
The frontline drugs for malaria — artemisinin-based combination therapies — have held for decades, but a growing body…
Studies
JAK/STAT Pathway Review Maps Therapeutic Gaps in Autoimmune, Malignant, and Other Disease Areas
Understanding why some people respond to anti-inflammatory drugs while others develop resistance or serious side…
Studies
Mendelian Randomization Study Links Genetic Proxies of GLP-1 Receptor Activity to Lower Breast/Prostate Cancer Risk and Higher Thyroid Cancer Risk
Drug-target Mendelian randomization using genetic variants in the GLP1R gene region as instruments—analyzed across 21…
Supplements
GLP-1 Agonists Boost Mitochondrial Bioenergetics, Cut ROS by 3.5 SMD in Human Cells
Pooling 17 in vitro studies using human-derived cell models, this meta-analysis found that GLP-1 receptor agonists…
Longevity
Gut Microbiome Metabolites Pipecolic Acid & Succinate Block Muscle Atrophy in Mice
Transferring cecal contents from exercise-trained female mice into sedentary, immobilized recipients significantly…
Longevity
ASAP3 Deficiency Alleviates Hepatic Senescence and Correlates with Extended Healthspan in Mice via Actin-Autophagy Axis
ASAP3, an actin cytoskeleton remodeling protein, is upregulated in aged mouse livers and H₂O₂-stressed hepatocytes…
Studies
Copper-64 PSMA-PET Detects 2.6x More Prostate Cancer Lesions Than Standard Gallium Imaging
For men whose prostate cancer returns after surgery, finding where it has spread is the decisive factor in whether…
Studies
Cannabis Use Disorder Linked to Nearly 4x Higher Lung Cancer Risk
As cannabis legalization spreads and cultural perceptions of its safety solidify, a critical assumption deserves…
Studies
Gut Bacterium's Ammonia Drives Liver Inflammation in MASH — Tripeptide Reverses It
For the millions living with fatty liver disease, the therapeutic landscape has long been frustratingly sparse. A new…
Studies
Gene-Edited Islet Cells Survive 12 Weeks in Diabetic Patient Without Immunosuppression
For decades, one of the most stubborn barriers in transplant medicine has been the immune system's refusal to tolerate…
Studies
Global Meningitis Kills 259,000 Yearly; Children Under Five Bear Heaviest Burden
Meningitis continues to exact a devastating toll despite decades of vaccine development and public health campaigns…
PREPRINTNutrition
Bhaktapur Nepal Women's Postpartum Obesity Surges 6x in Two Decades
Among 800 Nepalese women in Bhaktapur tracked from early pregnancy through 12 months postpartum (2017–2021), mean BMI…
PREPRINTStudies
PD-1 Inhibitors Associated with 81% Higher Cardiotoxicity Risk in 2,427 Lung Cancer Patients
Among 2,069 lung cancer patients with cardiac biomarker data drawn from a 2018–2024 Renji Hospital cohort, 15.8% (326…
PREPRINTLongevity
Abdominal Subcutaneous Fat (Not Visceral) Linked to 1.64-Fold Heart Failure Risk via Mendelian Randomization; ~68% Mediated by Cardiometabolic Pathways
Mendelian randomization analysis of genome-wide association data reveals that MRI-derived abdominal subcutaneous…
PREPRINTNutrition
UPF-Heart Disease Links Hold Despite Widespread Methodological Flaws in 46 Studies
A systematic review and meta-analysis of 46 studies finds that higher ultra-processed food (UPF) consumption is…
PREPRINTFitness
NHS Digital Falls App Boosts Balance by 6.35 Points, Cuts Costs in 202-Person RCT
Among 202 community-dwelling adults aged 60+ (mean 76.8 years, 73% female), the NHS-approved Keep-on-Keep-Up (KOKU)…
Supplements
Resveratrol Restores Diaphragm Function in Epilepsy via SERCA2/Calcium Pathway
Chronic epilepsy—modeled via pentylenetetrazol (PTZ) in 32 male Wistar rats—produced measurable diaphragm contractile…
Studies
US Kidney Transplants Hit Record 27,660 but Organ Discard Rates Climb
The gap between transplantable kidneys and patients who actually receive them remains one of transplant medicine's…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.