Studies
RNF43 Loss Rewires Pancreatic Cancer Metabolism via YBX1-MYC-OXPHOS Axis
Pancreatic ductal adenocarcinoma remains one of oncology's most lethal challenges, with five-year survival rates still…
Longevity
Senolytic Compounds Prevent Spinal Degeneration and Pain in Aging Mouse Model
Chronic back pain is one of the most prevalent and costly musculoskeletal conditions globally, yet most interventions…
Studies
Triple Receptor Agonist Retatrutide Cuts HbA1c and Weight in Phase 3 Diabetes Trial
The incretin pharmacology arms race has a new contender with meaningful clinical data behind it. For the millions of…
Studies
AI Surgical Decision Support: Impressive Progress, Persistent Gaps Remain
The gap between what AI promises and what it reliably delivers in the operating room has never been more consequential…
Studies
Risk Algorithm Detects Chlamydia/Gonorrhea Twice as Often as Rwanda National Guidelines
Undetected sexually transmitted infections during pregnancy carry serious consequences — preterm birth, neonatal…
Longevity
Theoretical Framework Links Visceral Adipose Tissue to Immunometabolic Decline in Osteosarcopenic Obesity
When fat, muscle, and bone deteriorate simultaneously in older adults, the compounding effect on frailty and fracture…
Studies
Triple Hormone Agonist Retatrutide Cuts HbA1c and Body Weight in Phase 3 Trial
For the millions of adults managing early-stage type 2 diabetes on diet and exercise alone, a new class of injectable…
Studies
STK40 Kinase Suppresses Kidney Fibrosis via STAT3 Ubiquitination Checkpoint
Chronic kidney disease affects roughly 850 million people worldwide, and fibrosis — the progressive scarring of renal…
Studies
Global Mental Disorder Burden Rose Steadily From 1990 to 2023
Mental health has long been the understated dimension of the global disease burden — underfunded, under-measured, and…
Studies
MicroRNA-203 Attenuates Cardiac Failure Via IGFBP5 Suppression in Preclinical Models
Heart failure driven by chronic pressure overload — as occurs in longstanding hypertension or aortic stenosis…
Studies
Substance P Signaling in Brain Pathway Drives Both Pain Sensitivity and Emotional Suffering
Chronic neuropathic pain is notoriously difficult to treat precisely because it has two distinct dimensions — the…
Studies
Targeted Agents and Immunotherapy Reshape Treatment Landscape for Aggressive TNBC Subtype
Triple-negative breast cancer represents one of oncology's most stubborn challenges — a subtype defined by the absence…
Studies
Lactate-Driven Histone Modification Enables Immune Escape in Aggressive Breast Cancer
Triple-negative breast cancer remains one of oncology's most frustrating challenges precisely because it lacks the…
Studies
Triple Receptor Agonist Retatrutide Cuts HbA1c and Body Weight in Phase 3 Trial
For the millions of adults managing type 2 diabetes with lifestyle modification alone, the pipeline of incretin-based…
Studies
Irradiated Tumor Fibroblasts Enter Senescence Yet Fuel Cancer Regrowth
Radiation therapy's failure to cure a third of advanced head and neck cancers has long puzzled oncologists, and this…
Studies
Explainable AI Skin Diagnostics Help Doctors But May Mislead Patients
The promise of AI-assisted diagnostics hinges on a critical assumption: that making AI more transparent improves…
Studies
Dual Microneedle Patch Closes Glucose-Insulin Loop in Diabetic Rats
Wearable closed-loop diabetes management has long been the holy grail of endocrinology engineering — a system that…
PREPRINTFitness
Peak Heart Rate Outperforms Cardiac Output in Predicting Walking Capacity for 211 Hypertensive Patients
Among 211 hypertensive patients assessed with impedance cardiography (ICG) during exercise, maximum heart rate (HRmax)…
PREPRINTLongevity
New Statistical Framework Identifies Stable Biomarkers for Post-Surgery Recovery in Older Adults
A new resampling-based statistical framework called Exploratory Stability Selection (ESS) was applied to the…
PREPRINTLongevity
Muscle Functional Capacity Modifies Association Between Adiposity and Sarcopenia in Two Large Cohorts
Across two large population-based cohorts — CHARLS (n=15,701 Chinese adults) and NHANES (n=10,730 Americans) — higher…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.