Studies
KRAS Inhibitors Show Potent Preclinical and Clinical Activity in Rare Appendiceal Cancer
Appendiceal adenocarcinoma is one of oncology's orphan diseases — so rare that standard chemotherapy regimens borrowed…
Nutrition
Sarcopenia and Type 2 Diabetes Share Bidirectional Molecular Pathways Accelerating Muscle Loss
For aging adults managing blood sugar, muscle loss is not merely a side effect — it may be an active accelerant of…
Studies
Transcription Factor Drug Targeting: Why Cancer's 'Undruggable' Proteins May Yield
For decades, the proteins that control which genes get switched on or off inside cancer cells were considered…
Studies
Gestational Hypertension Linked to 3.5-Fold Higher Long-Term Hypertension Risk in 15-Year Cohort Study
For women who have experienced complications during pregnancy, the cardiovascular consequences can extend far beyond…
Longevity
Epigenetic Clock Reversal May Offer New Path for Disc Degeneration Treatment
Low back pain affects hundreds of millions of adults globally, yet virtually every clinical intervention — from…
Studies
NEJM Review Reframes Platelet-Activating Anti-PF4 Disorders as Unified Disease Class
Understanding why some people develop dangerous clotting after heparin exposure—or even certain vaccines—has taken on…
Studies
Tau Spread Pattern Reveals Two-Phase Alzheimer's Progression Across Four Cohorts
Understanding exactly when and where Alzheimer's pathology becomes detectable — and measurable — has enormous…
Studies
FASN Overexpression Predicts Early Recurrence in Rare Peritoneal Cancer After Surgery
For one of the most difficult-to-treat abdominal cancers, identifying who will relapse early after aggressive combined…
Studies
GLP-1 Agonists Linked to Lower AUD Relapse Rates Than Standard Meds in Retrospective Stanford Study of Metabolic Patients
The expanding therapeutic profile of GLP-1 receptor agonists may be rewriting treatment calculus for a patient…
Studies
Biologic Therapy Linked to 44% Lower Psoriatic Arthritis Risk in Large Cohort
For the roughly 30% of psoriasis patients who eventually develop psoriatic arthritis, the question of whether…
Studies
Hybrid Graph-Transformer Model Advances Computational Drug-Target Binding Prediction
Every drug candidate that fails late in development represents years of research and hundreds of millions in wasted…
PREPRINTLongevity
IL34 Stop-Gain Variant Associated with Event-Free Survival in French-Canadian FH Patients (Preprint)
Among 243 French-Canadian carriers of the LDLR p.Trp87Gly pathogenic variant, whole-exome sequencing identified a…
PREPRINTLongevity
Statins Cut DNMT3A-Mutant Clonal Hematopoiesis Risk 22–34% via Non-LDL Mechanism
In a UK Biobank analysis of 416,118 adults, statin users showed 7% lower odds of DNMT3A-mutant clonal hematopoiesis…
PREPRINTLongevity
Sex-Specific Protein Signatures Split HFpEF Into 2 Distinct Risk Groups
Applying Similarity Network Fusion to 92 circulating inflammatory proteins and 49 clinical variables in 698 HFpEF…
PREPRINTLongevity
Female Depression Uniquely Predicts Dementia Risk Across 190+ Nations
A cross-national ecological analysis using Institute for Health Metrics and Evaluation data from countries worldwide…
PREPRINTLongevity
79% Vitamin D Deficiency Found Alongside 58% Obesity in Kazakhstan Care Home Elders
Among 62 adults aged 60+ (mean age 74) residing in a state social-care facility in Astana, Kazakhstan, a striking…
Studies
Semaglutide Maintains Glycemic Control for 5 Years in One LADA Case Without Insulin
A 55-year-old woman with LADA, class II obesity, and four concurrent autoimmune conditions—vitiligo, celiac disease…
Studies
Narrative Review: Liraglutide + Metformin Achieved 69% Pregnancy Rate in One Small PCOS Trial
GLP-1 receptor agonists (GLP-1RAs) are demonstrating meaningful reproductive signal in women with polycystic ovary…
Supplements
Silymarin Cuts Amyloid-Beta and SASP Markers in Senescent Mouse Brains
In a five-group mouse model combining doxycycline-accelerated cellular senescence (21 days) with…
Longevity
Review Maps Senescent Cells and Inflammaging Across Six Organ Systems, Highlighting Senolytic Potential
Chronic accumulation of senescent cells — those locked in irreversible cell cycle arrest while secreting…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.