PREPRINTStudies
Only 9% of Hypertension Trials Report Results on Time: 5,851-Trial Analysis
A cross-sectional meta-research analysis of 5,851 registered hypertension trials on ClinicalTrials.gov found that…
PREPRINTLongevity
AI Pose Estimation Accurately Extracts Gait Parameters from Walking Videos, Revealing Differences Across Frailty Stages in 68 Older Adults
Smartphone-accessible AI pose estimation applied to walking videos accurately quantified gait differences across 68…
PREPRINTWellbeing
Visual Cues Backfire: Simpler CCT Instructions Boost Acceptance in 128 Seniors
In a within-subjects experiment with 128 adults aged 65+ (mean age 71.5, 70% female), simpler instructions lacking…
Supplements
Oral GLP-1 Drugs Deliver 11–12% Weight Loss Without Injections in Non-Diabetics
A frequentist random-effects network meta-analysis pooling 9 RCTs (N = 5,766; durations 20–72 weeks) compared four…
Longevity
40 Years of Data: Loneliness Linked to Immune Aging via Gut-Inflammation Pathways in Kiecolt-Glaser Review
Four decades of psychoneuroimmunology research from Kiecolt-Glaser's lab at Ohio State establishes a robust causal…
Wellbeing
Psilocybin Reshapes Fronto-Striatal-Thalamic Circuits Four Weeks Post-Dose
Understanding why a single psychedelic session can produce psychiatric benefits lasting weeks or months has been one…
Wellbeing
Apical Dendrite Hyperactivation May Explain Psychedelics' Therapeutic Consciousness Effects
Understanding precisely why psychedelic compounds alter consciousness so profoundly—and why those alterations…
Studies
ER Staff Show Lower Regard for Overdose Patients, Especially White-Presenting Ones
Stigma in emergency medicine doesn't operate uniformly — it shifts depending on both the diagnosis and the patient's…
Studies
Omega-3 Plus Low-Dose Aspirin Rivals Antibiotics for Severe Periodontitis
For the millions of adults living with severe gum disease, the assumption that antibiotics are the gold standard…
Studies
Reasoning AI Models Embed Racial and Gender Bias Across 36,000 Clinical Cases
As AI-assisted clinical decision support moves from concept to bedside reality, the assumption that more sophisticated…
Studies
D-Serine Suppresses Anti-Tumor Immunity by Rewiring Macrophage Signaling
Understanding why some cancer patients fail to respond to immunotherapy is one of oncology's most pressing puzzles. A…
Studies
PPM1H Loss Ties LRRK2-RAB Hyperphosphorylation to Alpha-Synuclein Buildup
For anyone tracking the molecular roots of Parkinson's disease, understanding exactly how protein clumps form in…
Longevity
Medicare HIV Population Projected to Rise ~60% by 2035, Costs Surge
The aging of the HIV-positive population is quietly reshaping one of the most complex intersections in American…
Studies
Lutetium-177 PSMA Therapy Moves Earlier in Prostate Cancer Treatment Cascade
For the roughly 300,000 men diagnosed annually with prostate cancer in the United States alone, the sequencing of…
Studies
FMF Linked to Broad Autoimmune Cascade Across Two Decades of Follow-Up
Familial Mediterranean fever has long been considered a periodic fever syndrome managed largely in isolation, but…
Studies
Dexrazoxane Cardioprotection Now Standard for High-Dose Pediatric Leukemia Treatment
For children who survive leukemia, the cancer itself may not be the final threat to their health — the treatments that…
Studies
Global Mental Disorder Burden Rose Sharply Across 204 Countries, 1990–2023
Mental illness has quietly become one of the defining public health challenges of our era — not because it is newly…
Studies
mRNA-Exosome Cancer Vaccines Reprogram Tumor Immunity via Epigenetic Mechanisms
The frontier of cancer immunotherapy is shifting in a way that challenges a long-held assumption: that mRNA technology…
Longevity
Methionine Restriction Extends Lifespan via PP2A Methylation and Autophagy Cascade
For adults curious about longevity nutrition, the question has never been whether methionine restriction works — it…
Studies
Tumor Immune Composition Predicts Long-Term Tamoxifen Response in ER+ Breast Cancer
For the roughly 70% of breast cancers that are estrogen receptor-positive, tamoxifen has been a cornerstone therapy…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.