PREPRINTLongevity
AI-Guided Self-Titration Hits 88% Time-in-Range for Heart Failure Patients in 90-Day Trial
Applying the insulin self-management paradigm to heart failure, the SURPASS-HF trial enrolled 21 adults (mean age…
PREPRINTLongevity
RCRI Score ≥3 Associated with ~49-Fold Higher Odds of Unplanned Surgical Admission in ATTR-CM Patients (Preprint)
Among 51 ATTR-CM patients undergoing non-cardiac surgery drawn from a 145-patient real-world cohort, a Revised Cardiac…
PREPRINTLongevity
Wearable NIRS Shows Differences in Heart Failure Patients With Identical 6-Minute Walk Distances: medRxiv Pilot Study
In a 44-patient pilot study of chronic heart failure outpatients (mean age 70.9 years), wearable near-infrared…
Studies
Global Mental Disorder Burden Mapped Across 204 Nations Over Three Decades
Mental health has long been underfunded relative to its share of global disease burden, and this landmark analysis…
Studies
Bidirectional Neuroprosthesis Yields Lasting Hand Recovery After Complete Tetraplegia
For the millions living with spinal cord injury, the prospect of regaining not just movement but sensation — and…
Studies
GLP-1 Agonists Show No Clear Advantage Over Other Agents for Insulin Discontinuation
For the millions of people with type 2 diabetes who take daily basal insulin injections, the prospect of eventually…
Studies
Immunopeptidomics Uncovers Conserved Malaria Antigens Enabling Cross-Stage Vaccine Design
The possibility of a single vaccine offering protection against multiple species of malaria — and across the…
Longevity
GPR40 Receptor Activation Reverses Thymic Aging in Mouse Model
Immune deterioration with age has long been attributed partly to the shrinking thymus, but pinning down a druggable…
Longevity
SIRT3 Loss in Aging Stem Cells Drives Chronic Inflammation Via Myeloid Reprogramming
One of the most persistent puzzles in aging biology is explaining why the immune system shifts from a protective force…
Studies
Dual HIF-1/2 Inhibitor Achieves 50%+ Complete Responses in Mouse Models of Five Cancer Types
One of the most stubborn challenges in oncology is that tumors engineer their own survival environment — starving…
Wellbeing
One-Third of US Women Uncertain About Perimenopause Stage, Survey Finds
Perimenopause remains one of the most clinically under-served transitions in women's health, and a major reason may be…
Longevity
Lp(a): Genetic Cardiovascular Risk Factor Affecting 20% Awaits Targeted Therapies
For roughly one in five adults, cardiovascular risk is quietly elevated by a factor that standard lipid panels often…
Studies
GLP-1 Drugs May Both Help and Harm Patients With Eating Disorders
As GLP-1 receptor agonist prescriptions continue to surge globally, a critical blind spot is emerging: the millions of…
Supplements
Melatonin Shows Modest Pain Relief in Chronic Musculoskeletal Conditions, Meta-Analysis Finds
For the millions of adults managing chronic joint, back, or soft-tissue pain, the appeal of a non-opioid…
Studies
A2AR Receptor Loss Paradoxically Accelerates CD8 T Cell Exhaustion via IL-2 Signaling
One of the central ambitions in cancer immunotherapy is sustaining the killing power of CD8+ T cells long enough to…
Studies
GLP-1 Weight Loss Patients Choose Different Body Contouring Than Bariatric Patients
As GLP-1 receptor agonists reshape how millions achieve significant weight loss, a clinically important question…
Wellbeing
MEG Reveals How Aging Rewires Brain Networks During Noisy Speech Comprehension
Understanding why older adults struggle in noisy environments has long been attributed primarily to peripheral hearing…
Nutrition
Mediterranean Diet Cuts HbA1c and Reshapes Gut Microbiome in Diabetes-Risk Adults
For the roughly one-in-three adults who live with prediabetes or elevated cardiovascular risk, diet remains the most…
Studies
Mutant KRAS Peptide Vaccine Generates Durable T-Cell Immunity in Pancreatic Cancer Prevention Trial
Pancreatic cancer kills the vast majority of those diagnosed because it is almost never caught early — but what if the…
Studies
Tanzania Phase 1/2 Trial Tests Intranasal COVID Vaccine for Equity Gaps
Vaccine access inequity remains one of the most persistent structural failures exposed by the COVID-19 pandemic, and…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.